SUMMARY
Markovskaya E. V., Shapkin A. S. ??????????????????? ????????? ?????????????? ??????? ??????? ??? ?????????? ???????? = Pathological changes of peripheral nervous system in multiple sclerosis. Journal of Education, Health and Sport. 2016;6(8):267-283. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.60514http://ojs.ukw.edu.pl/index.php/johs/article/view/3758 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.08.2016. Revised 08.08.2016. Accepted: 19.08.2016. ??????????????????? ????????? ?????????????? ??????? ??????? ??? ?????????? ???????? ?. ?. ??????????, ?. ?. ?????? ??????????? ???????????? ??????????? ??????????? ??????????????? ???????????? ??????????????????? ????????? ?????????????? ??????? ??????? ? ??????? ???? ? ??????? ?????????? ?????????. ????????, ??? ? ????????? ?????????????? ??????? ??????? ??? ?????????? ???????? ????????? ?????????????? ? ?????????????? ????????? ??????? ??????? ? ???? ?????????????, ????????, ??????????? ??????? ? ????????? ?????????? ??????????? ??????. ? ?????????????? ? ??????????????? ???????????? ???? ?????????? ?????????????? ?????????, ??? ???? ? ??????? ?????????????? ??????????????? ??????????? ??????????????? ??????? ?????????? ???????????????-2 ? ????????????? ??????? ??????? ?????? ?????. ????? ?? ??????? ??????????, ??????????? ?????????????? ? ?????????????? ????????? ??????? ???????, ????? ??????? ????????? ? ??????????? ??????? ????????????? ??????? ??????? ?????? ????? ? ???????????????-2. ??????? ?????????????? ?????????? ? ?????????????? ????????? ? ??????????? ?????????????? ??????? ??????? ??? ?????? ????? ??????? ??????????? ????????, ? ??? ????? ? ? ?????? ????????, ??????? ????????? ??? ?????????? ???????????????? ???????.???????? ?????: ?????????? ???????, ??????????, ?????????????? ??????????. Pathological changes of peripheral nervous system in multiple sclerosis E. V. Markovskaya, A. S. Shapkin Kharkiv National Medical University AbstractScientific research of pathomorphological changes of peripheral nervous system and skin vessels in patients with multiple sclerosis was done. It was marked that demyelination and dystrophic changes in nerves in form of stratification, varicose distension, sclerosis and local decreasing of Schawann cells are detected. Inflammatory changes in perineural and perivascular space of the skin were revealed, increased level of cyclooxygenase-2 and inducible nitric oxide synthase in lymphocytic inflammatory infiltration are expressed. One of pathogenetic mechanism leading to demyelination could be activation of inducible nitric oxide synthase and cyclooxygenase-2 inSchwann cells. So, endothelial dysfunction and inflammatory changes in elements of peripheral nervous system in different types of courses of multiple sclerosis, also in remission, should be taking into consideration for prescribing pathogenetic treatment. Key words: multiple sclerosis, morphology, endothelial dysfunction. ???????????????? ????? ???????????? ???????? ??????? ??? ?????????? ???????? ?. ?. ??????????, ?. ?. ?????? ??????????? ???????????? ???????? ??????????? ??????????????? ??????????? ????????????????? ???? ???????????? ???????? ??????? ? ????? ????? ? ?????? ?? ????????? ???????. ??????????, ?? ? ????????? ???????????? ???????? ??????? ??? ?????????? ???????? ????????? ?????????????? ?? ??????????? ????? ???????? ??????? ? ??????? ?????????????, ????????, ??????????? ?????? ? ???????????? ????????? ???????????? ??????. ? ??????????????? ? ???????????????? ????????? ????? ??????????? ???????? ?????, ??? ????? ? ???????? ?????????????? ?????????? ??????????? ????????????? ?????? ????????? ???????????????-2 ? ??????? ????????????? ??????? ?????? ?????. ????? ? ????? ??????????, ?? ?????????? ?????????????? ? ??????????? ????? ???????? ???????, ???? ??????? ????????? ? ???????????? ????????, ????????????? ??????? ??????? ?????? ????? ?? ???????????????-2. ????????? ?????????????? ?????????? ? ????????? ???? ? ??????????? ???????????? ???????? ??????? ??? ?????? ????? ???????? ??, ? ???? ????? ? ? ?????? ???????, ???? ??????????? ??? ??????????? ?????????????? ???????. ??????? ?????: ????????? ???????, ??????????, ????????????? ??????????.