SUMMARY
The increasing number of tobacco users will directly impact to an increase in the number of passive smokers. Various harmful substances that enter the respiratory tract can cause health problems. The airway will recognize these substances as pathogen and activate immune response accordingly. In?ammatory response becomes one of the e?ects of body compensation due to an increased pathogen. This e?ect is indicated by the elevation of C-Reactive Protein as one systemic in?ammatory response parameters in the body. This study aimed to determine the e?cacy of red mulberry juice to reduce levels of C-Reactive Protein in Wistar rats because exposure to cigarette smoke. This is an experimental study with a post-test control group design. Animals were divided into negative control group, positive control group, and 3 treatment groups with di?erent red mulberry doses. The positive control group showed the highest increase in C-Reactive Protein levels compared with the red mulberry intake group (p<0,001). In conclusion, the administration of red mulberry juice can reduce in?ammatory response in rats because of exposure to cigarette smoke.