SUMMARY
Patent foramen ovale (PFO) is a remnant of an embryological atrial communication, which normally closes spontaneously after birth. However, it remains open in 25% of the general population. It is linked to several conditions due to a right-left shunt, including cryptogenic ischemic stroke, systemic embolism, migraine, and decompression illness. Percutaneous PFO closure is a relatively simple and safe procedure, which has been indicated in selected patients. Results from relevant studies show that closure is reasonable in younger patients with embolic ischemic stroke, where after thorough and comprehensive diagnostics and exclusion of alternative causes, the cause still remains undetermined. Even after percutaneous closure of PFO, lifelong secondary medical treatment is mandatory. To date, the results of the studies show that percutaneous closure is not indicated in the treatment of migraine, but is indicated in active and professional divers after decompression illness. Patients with an indication for percutaneous PFO closure should be referred to a multidisciplinary PFO council.