Jenis dan Efek Complementary Therapy dalam Menurunkan Tekanan Intra Okular (TIO) pada Pasien Glaukoma: A Systematic Review
Types and Effects of Complementary Therapy in Reducing Intra-Ocular Pressure (IOP) in Glaucoma Patients: A Systematic Review
DOI:
https://doi.org/10.25026/jsk.v3i3.471Keywords:
Glaucoma; Complementary Therapy; intraokular pressureAbstract
Galukoma merupakan salah satu penyebab utama kebutaan permanen diseluruh dunia dan diprediksi akan mengalami peningkatan pada tahun 2040 menjadi 111.8 juta orang. Peningkatan TIO merupakan salah satu penyebab utama terjadinya glaukoma. Saat ini, pengobatan glaukoma berfokus pada penurunan TIO dengan terapi farmakologis dan intervensi bedah. Namun, penggunaan terapi anti-glaukoma seringkali sulit dilakukan karena membutuhkan komitmen seumur hidup serta adanya efek samping pengobatan. Intervensi Complementary therapy dapat juga mengurangi efek samping pengobatan, mengurangi stress dan berperan dalam menurunkan TIO pada pasien glaukoma. Penelitian ini bertujuan untuk mengidentifikasi jenis dan efek complementary therapy dalam menurunkan tekanan intra okular pada pasien glaukoma. Desain yang digunakan adalah systematic review. Pencarian menggunakan lima database PubMed, ProQuest, Ebsco, Chocrane Library dan Google Scholar, selain itu dilakukan secondary searching untuk mengidentifikasi jenis dan efek complementary therapy yang dapat menurunkan TIO pada pasien glaukoma, dipublikasikan 10 tahun terakhir (2010-2020), full text, desain studi RCT dan berbahasa Inggris. Hasil penelitian ini ditemukan sebelas studi yang diinklusi dan direview. Dari ulasan tersebut ada tiga klasifikasi complementary therapy yang ditemukan yaitu Energy Therapy (akupuntur, akupresur dan TENS) yang bermanfaat dalam menurunkan TIO dengan menurunkan aktivitas sistem saraf simpatis, Mind-Body Spirit Therapy (musik dan meditasi) yang berperan dalam menurunkan kortisol dan meningkatkan endorphin yang berkorelasi dalam penurunan TIO, Biological Based Therapies (ekstrak saffron) sebagai antioksidan dan pelindung saraf, mengurangi spesies oksigen reaktif dan menghambat kematian sel Trabecular Meshwork yang berperan dalam pengurangan TIO.
Kesimpulan dari penelitian ini, Complementary Therapy dapat digunakan sebagai tambahan pengobatan konvensional dalam menurunkan TIO pada pasien glaukoma.
References
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[11] Balasopoulou et al., “Lasers in glaucoma,” BMC Ophthalmol., vol. 17, no. 1, p. 1, 2017.
[12] Conlon, H. Saheb, and I. I. K. Ahmed, “Glaucoma treatment trends: a review,” Can. J. Ophthalmol., vol. 52, no. 1, pp. 114–124, 2017.
[13] Dikopf, T. S. Vajaranant, and D. P. Edward, “Topical treatment of glaucoma: established and emerging pharmacology,” Expert Opin. Pharmacother., vol. 18, no. 9, pp. 885–898, 2017.
[14] Anwar, S. R. Wellik, and A. Galora, “Glaucoma therapy and ocular surface disease: Current literature and recommendations,” Curr. Opin. Ophthalmol., vol. 24, no. 2, pp. 136–143, 2013.
[15] Aguayo Bonniard, J. Y. Yeung, C. C. Chan, and C. M. Birt, “Ocular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK),” Expert Opin. Drug Metab. Toxicol., vol. 12, no. 11, pp. 1279–1289, 2016.
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[18] Kim et al., “Acupuncture for the treatment of dry eye: A multicenter randomised controlled trial with active comparison intervention (artificial teardrops),” PLoS One, vol. 7, no. 5, pp. 1–9, 2012.
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[21] Wu, X. Wi Zhou, L.-L. Mi, B. Cheng, and X. Cai, “Effects of acupuncture, tuina combined with phacoemulsification for cataract with glaucoma,” vol. 39, no. 2, pp. 156–159, 2019.
[22] Guo et al., “Effect of ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: A randomized, crossover clinical trial,” Investig. Ophthalmol. Vis. Sci., vol. 55, no. 1, pp. 110–116, 2013.
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[29] J. P. T. Higgins, D. G. Altman, P. C. Gøtzsche, P. Jüni, D. Moher, and A. D. Oxman, “The Cochrane Collaboration ’ s tool for assessing risk of bias in randomised trials,” pp. 1–9, 2011.
[30] M. H. J. Bonyadi, S. Yazdani, and S. Saadat, “The ocular hypotensive effect of saffron extract in primary open angle glaucoma: A pilot study,” BMC Complement. Altern. Med., vol. 14, no. 1, pp. 1–6, 2014.
[31] Chen, F. S. Yieh, W. L. Liao, T. C. Li, and C. L. Hsieh, “Effect of Acupuncture on Intraocular Pressure in Glaucoma Patients: A Single-Blinded, Randomized, Controlled Trial,” Evidence-based Complement. Altern. Med., vol. 2020, 2020.
[32] Dada et al., Effect Of Mindfulness Meditation On Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomised Controlled Trial. India: Elsevier Inc., 2020.
[33] Dada et al., “Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in Glaucoma: A randomized controlled trial,” J. Glaucoma, vol. 27, no. 12, pp. 1061–1067, 2018.
[34] Gagrani et al., “Meditation enhances brain oxygenation, upregulates BDNF and improves quality of life in patients with primary open angle glaucoma: A randomized controlled trial,” Restor. Neurol. Neurosci., vol. 36, no. 6, pp. 741–753, 2018.
[35] Law, Lowe, S. M. Law, J. A. Giaconi, A. L. Coleman, and J. Caprioli, “Prospective Evaluation of Acupuncture as Treatment for Glaucoma,” Am. J. Ophthalmol., vol. 160, no. 2, pp. 256–265, 2015.
[36] Yeh, J. C. Lin, and C. F. Liu, “Effect of transcutaneous electrical nerve stimulation through acupoints of Pucan (BL 61) and Shenmai (BL 62) on intraocular pressure in patients with glaucoma: a randomized controlled trial,” J. Tradit. Chin. Med., vol. 36, no. 1, pp. 51–56, 2016.
[37] Her et al., “Intraocular pressure-lowering effect of auricular acupressure in patients with glaucoma: A prospective, single-blinded, randomized controlled trial,” J. Altern. Complement. Med., vol. 16, no. 11, pp. 1177–1184, 2010.
[38] Leszczynska, L. Ramm, E. Spoerl, L. Pillunat, and N. Terai, “‘the short-term effect of acupuncture on different ocular blood flow parameters in patients with primary open-angle glaucoma: A randomized, clinical study,’” Clin. Ophthalmol., vol. 12, pp. 1959–1960, 2018.
[39] Bertelmann and I. Strempel, “‘short-term effects of relaxation music on patients suffering from primary open-angle glaucoma,’” Clin. Ophthalmol., vol. 9, pp. 2321–2323, 2015.
[40] Ibrahim Ali and Fahmy, “Acupuncture as Additional Therapy for Modulation of Intraocular Pressure in Patient with Open Angle Glaucoma Authors,” J. Med. Sci. Clin. Res., vol. 03, no. 07, pp. 6781–6789, 2015.
[41] Sabel, J. Wang, L. Cárdenas-Morales, M. Faiq, and C. Heim, “Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine,” EPMA J., vol. 9, no. 2, pp. 133–160, 2018.
[42] Lindquist, M. F. Tracy, and M. Snyder, Complementary and Alternative Therapies in Nursing, 8th ed. New York: Springer Publishing Company, 2018.
[43] Chu and D. E. Potter, “Ocular hypotension induced by electroacupuncture,” J. Ocul. Pharmacol. Ther., vol. 18, no. 4, pp. 293–305, 2002.
[44] Han Ji-Sheng, “Acupuncture:neuropeptide release produced by electrical stimulation of different frequencis,” TRENDS Neurosci., vol. 26, no. 1, pp. 17–21, 2003.
[45] Kurusu et al., “Acupuncture For Patients With Glaucoma,” Explor. J. Sci. Heal., vol. 1, no. 5, pp. 372–376, 2005.
[46] Assimopoulou, Z. Sinakos, and V. P. Papageorgiou, “Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents,” Phyther. Res., vol. 19, no. 11, pp. 997–1000, 2005.
[47] Izzotti, S. C. Saccà, M. Longobardi, and C. Cartigl, “Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of Glaucoma,” Investig. Ophthalmol. Vis. Sci., vol. 50, no. 11, pp. 5251–5258, 2009.
[48] Jia, Sun, Fan, Lam, C. P. Pang, and G. H. F. Yam, “Effect of Topical,” vol. 126, no. 12, pp. 1700–1706, 2008.
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Published
2021-06-30
How to Cite
Rerung, S. I., Said, S., & Erika, K. A. (2021). Jenis dan Efek Complementary Therapy dalam Menurunkan Tekanan Intra Okular (TIO) pada Pasien Glaukoma: A Systematic Review : Types and Effects of Complementary Therapy in Reducing Intra-Ocular Pressure (IOP) in Glaucoma Patients: A Systematic Review . Jurnal Sains Dan Kesehatan, 3(3), 544–555. https://doi.org/10.25026/jsk.v3i3.471
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