PROSPECTS OF SURFACTANTS OF MICROBIAL ORIGIN IN THE MEDICINAL AND COSMETIC PRODUCTS

Анотація

PROSPECTS OF SURFACTANTS OF MICROBIAL ORIGIN IN THE MEDICINAL AND COSMETIC PRODUCTS

I. R. Pelekh¹, S. B. Bilous¹, R. I. Vildanova², O. M. Shulha²

¹Danylo Halytskyi Lviv National Medical University

²Department of Physical Chemistry of Fossil Fuels InPOCC, NAS of Ukraine, Lviv

Introduction. In recent years there is a steady trend towards production of drugs for skin application and cosmetic products with a high content of aqueous phase, protein, natural lipid components and extracts (gels, moistening creams, cosmetic milk and others). However, these products require the use of significant amounts of auxiliary components such as emulsifiers, solubilizers and preservatives, because they are favorable environment for the development of micro-organisms that can cause diseases of skin and mucous membranes. So important is the search for new effective emulsifiers and preservatives for use in the medicinal and cosmetic products that also would not toxic, not allergenic namely safe for humans.

Investigation methods. In the arrticle the methods of information research, literature data analysis and marketing research were used.

  Results and discussion. In recent decades a new class of products of microbial synthes is being actively researched  - biogenic surfactants or biosurfactants. Biosurfactants have the same physical and chemical properties as synthetic surfactants: the value of critical micelle concentration, hydrophilic-lipophilic balance, surface and interfacial tension, and others are known.

Among the biosurfactants ramnolipides are the most effective, synthesized by the genus Pseudomonas and widely distributed in nature due to their ability to absorb a variety of substrates and grow in different environmental conditions.

Due to its molecular structure and, consequently, physical and chemical properties, ramnolipides can be widely used: for both new and to improve existing drugs for agriculture, cosmetics and medicine. Biosurfactants can be used as independent agents, as well as for creation of complex drugs with improved functional characteristics.

To date in medicine and cosmetics biosurfactants almost are not apply, but positive results, obtained in different laboratories around the world, give the reason to consider them as a replacement for synthetic surfactants. Due to the wide range of biological properties such as antimicrobial, antifungal, antivirus, antiadhezive and  emulsifying  biosurfactants have prospects for obtaining new effective medicines and cosmetics.

Conclusions. A variety of physical, chemical and biological properties of biogenic surfactants determines the prospects of their research as safe for human emulsifiers, stabilizers and preservatives in compositions of medicinal and cosmetic products.
References

1. Walters Y. Dermatologic, cosmeceutic and cosmetic development / Edit. Y.Walters. – 2008. – 644 p.
2. Walters K. Dermatological and transdermal formulations / Edited by Kenneth A.Walters. – NewYork-London. – 2007. – 565 p.
3. Nastanova 42-3.1:2004. Nastanovy  z  jakosti. Likars'ki zasoby. Farmacevtychna rozrobka. - Kyiv, 2004. – 15 s.
4. Praktykum z tekhnologii  likars'kykh kosmetychnykh zasobiv / T.H.Kalynyuk, E.V.Bokshan, S.B.Bilous [ta in.]. - K.: Medycyna, 2008 . - 184 s.
5. Tekhnologіa kosmetychnykh zasobіv: Navch. posіbnyk dlia stud. farmac. spec. vyshch. navch. zaklad. /O.H.Bashura, N.P.Polovko, T.M.Koval'ova [ta іn]. - Vіnnycia: Nova knyha, 2007. – 360s.
6. Toksykologіchna khіmіa kharchovykh produktіv ta kosmetychnykh zasobіv /S.A.Voronov, JU.B.Stecishin, Ju.V.Panchenko, V.P.Vasyl'ev – L.: Vydavnyctvo L'vіvs'koi  polіtekhnіky, 2010. – 316 s.
7. Dmytruk S.I. Farmacevticheskaja i medicinskaja kosmetologija: Uchebnik. – Tomsk: Izd-vo NTL, 2005. – 180 s.
8. Parkinson M. Biosurfactants / M. Parkinson  // Biotech. Advs. – 1985. - Vol.3. - P.65-83.
9. Sim L. Production and characterization of a biosurfactant isolated from Pseudomonas aeruginosa UW-1 / L. Sim, O.P. Ward, Zy. Li // J. Ind. Microbiol. Biotechnol. – 1997. – Vol. 19. – P. 232-238.
10. Physicochemical and antimicrobial properties of new rhamnolipid produced by Pseudomonas aeruginosa AT10 from soybean oil refinery wastes / A.Abalos, A.Pinazo, M.R. Infante [et al.] // Langmuir. – 2001. – Vol. 17, № 5. – P. 1367–1371.
11. Microbial biosurfactants production, applications and future potential / I.M.Banat, I.Franzetti, A.Gandolfi [et. al.] // Applied Microbiology and Biotechnology. – 2010. – Vol. 87. – P.427-444.
12. Interference in adhesion of bacteria and yeasts isolated from explanted voice prosthe-ses to silicone rubber by rhamnosolipid biosurfactants / L. R.Rodrigues, I. M.Banat, van der Mei H. C. [et al.] // J. Appl. Microbiol. — 2006. — Vol. 100, N 3. — P. 470-480.
13. Singh P. Potential applications of microbial surfactants in biomedical sciences / P.Singh, S.Cameotra // Trend. Biotechol. — 2004. — V. 22, N 3. — P. 142-146.
14. Das P. Antimicrobial potential of a lipopeptide biosurfactant derived from a marine Bacillus circulans / P.Das, S.Mukherjee, R.Sen // J. Appl. Microbiol. — 2008. — Vol. 104, N 6. — P. 1675-1684.
15. Haddad N. I. Isolation and characterization of a biosurfactant producing strain, Brevibacilis brevis HOB1 / N. I.Haddad, J.Wang, B.Mu // J. Ind. Microbiol. Biotechnol. — 2008. — Vol. 35, N 12. — P. 1597-1604.
16. Joshi S. Production of biosurfactant and antifungal compound by fermented food isolate Bacillus subtilis 20B / S.Joshi, C.Bharucha, A J. Desai // Bioresour. Technol. — 2008. — Vol. 99, N 11. — P.4603-4608.
17. Grover M. Molecular and biochemical approaches for characterization of antifungal trait of a potent biocontrol agent Bacillus subtilis RP24 / M.Grover, L.Nain, S. B.Singh [et al.] // Curr. Microbiol. — 2010. — Vol. 60, N 2. — P. 99-106.
18. Mimee B.  Antifungal activity of flocculosin, a novel glycolipid isolated from Pseudozyma flocculosa / B.Mimee, C.Labbe, R.Pelletier [et al.]  // Antimicrob. Agents Chemother. — 2005. — Vol. 49, N 4. — P. 1597-1599.
19. Rodrigues L.  Biosurfactants: potential applications in medicine / L. Rodrigues, I. M.Banat, J.Teixeira, R.Oliveira [et al.]  // J. Antimicrob. Chemother. — 2006. — Vol. 57, N 4. — P. 609-618.
20. Saini H.  Efficient purification of the biosurfactant viscosin from Pseudomonas libanensis strain M9-3 and its physicochemical and biological properties / H.Saini, B.Barragan-Huerta, A.Lebroan-Paler // J. Nat. Prod. — 2008. — Vol. 71, N 6. — P.1011-1015.
21. Rodrigues L.R.  Influence of biosurfactants from probiotic bacteria on formation of biofilms on voice prostheses / L.R.Rodrigues, van der Mei H.C., J.Teixeira [et al.]  // Appl. Environ. Microbiol. — 2004. — Vol. 70, N 7. — P. 4408-4410.
22. Lee S.  Isolation and structural analysis of bamylocin A, novel lipopeptide from Bacillus amyloliquefaciens LP03 having antagonistic and crude oil-emulsifying activity / S. Lee, S.Kim, S.Chung [et al.]  // Arch. Microbiol. — 2007. — Vol. 188, N 4. — P. 307-312.
23. Arutchelvi J. I. Mannosylerythritol lipids: a review / J. I.Arutchelvi, S.Bhaduri, P. V.Uppara [et al.]  // J. Ind. Microbiol. Biotechnol. — 2008. — Vol. 35, N 12. — Р. 1559-1570.
24. Yakimov M.  Characterization of a new lipopep-tide surfactant produced by thermotolerant and halotolerant subsurface Bacillus licheniformis BAS50 / M.Yakimov, K.Timmis, V.Wray [et al.]  // Appl. Envirol. Microbiol. — 1995. — Vol. 61, N 5. — P. 1706-1713.
25. Dubern J. F. Regulation of the biosynthesis of novel cyclic lipopeptides from Pseudomonas putida strain PCL1445: Ph. D  thesis. - ISBN: 90-9020584-5. - Ridderkerk, TheNetherlands, 2006. — 174 p.
26. Patrone V. In vitro synergistic activities of essential oils and surfactants in combination with cosmetic preservatives against Pseudomonas aeruginosa and Staphylococcus aureus / V.Patrone, R.Campana, E.Vittoria  [et al.]  // Ibid. — 2010. — Vol. 60, N 4. — Р. 237-241.
27. Cho Y. S.  Antibacterial effects of green tea polyphenols on clinical isolates of methicillin-resistant Staphylococcus aureus / Y. S.Cho, N. L Schiller, K. H. Oh // Ibid. — 2008. — Vol. 57, N 6. — Р. 542-546.
28. Bova T.O. Skrynіng rechovyn mіkrobnogo pokhodzhennja z antivіrusnoju aktyvnіstju in vitro / T.O.  Bova // Bіologіja tvaryn. – 2010. – T. 12, № 2. – S. 503 – 507.
29. Antyvіrusna aktyvnіst' bіosurfaktantu kul'tury Gordonia rubripertincta UKM As-122 / O.V.Karpenko, T.O.Bova, M.V. Prystaj [ta іn.] // Sіl's'kogospodars'ka mіkrobіologіja. – 2011. – Vyp. 13. – S.164 – 170.