Monitoring Terapi Warfarin pada Pasien Pelayanan Jantung pada Rumah Sakit di Bandung
Abstract
Penelitian ini bertujuan untuk mengetahui monitoring terapi warfarin untuk menjamin ketepatan dosis,
keamanan terapi, dan mengetahui apakah dosis terapi warfarin yang digunakan telah memenuhi kriteria penggunaan obat warfarin yang rasional. Derajat antikogulasi setiap pasien diukur dengan parameter waktu protrombin yang dinyatakan dengan International Normalized Ratio (INR). Metode Penelitian meliputi monitoring terapi warfarin terhadap 80 pasien di pelayanan jantung melalui PT-INR, pendataan
klinis pasien meliputi, usia, jenis kelamin, berat badan, tinggi badan, jenis penyakit, dosis yang digunakan dan obat lain yang dikonsumsi secara bersamaan. Hasil monitoring menunjukkan rata-rata INR pasien yaitu 1,38± 0,42 hasil ANAVA (α = 0,05) menunjukkan tidak ada pengaruh dosis terhadap INR
(p=0,13) tetapi ada pengaruh pada umur (p =0,014), hasil uji beda (α = 0,05) menunjukkan tidak ada perbedaan terhadap rata-rata INR berdasarkan jenis kelamin (p =0,051), umur (p =0,397), dan variasi dosis (p = 0,057). Hasil tersebut menunjukkan bahwa dosis warfarin belum mencapai target terapi INR (2–3).
Kata kunci: Warfarin, penyakit trombotik, PT-INR
Warfarin Therapy Monitoring of Cardiac Care Patients in Hospital in Bandung
Abstract
The aims of this study were to identify the rational warfarin monitoring therapy to guarantee the right
dose, therapy security, and whether the dose of warfarin therapy has completed the rational criteria or
not. Degree of antikoagulasi for each patient is measured with protombin time as International Normalized Ratio (INR). The methods consist of warfarin monitoring therapy towards 80 patients at the heart service through the PT-INR constant, medical data, such as age, gender, weight, height, type of the disease, dose usage and another medicine which is used together, and statistical test of the average of INR. The monitoring result shows that patient’s INR average is 1,38 ±0,42, the result of ANAVA (α=0,05)
shows that there’s no impact of dose towards INR (p=0,13) but there’s an INR average impact based
on gender (p=0,051), age (p=0,397) and dose variation (p=0,057). The results shown that warfarin dose which used is not bleeding risk.
Key words: Warfarin, trombotic disease, PT-INR
Keywords
Full Text:
PDF (Bahasa Indonesia)Dimension Citation Metrics Badge
Refbacks
- There are currently no refbacks.
Indonesian Journal of Clinical Pharmacy is indexed by
IJCP by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
View My Stats
Refbacks
- There are currently no refbacks.
Indonesian Journal of Clinical Pharmacy is indexed by