HIGH INTENSITY INTERVAL TRAINING DOES NOT CHANGE THE AREA IN THE ADIPOCYTES OF THE EPICARDIUM OF FAT RATS

  • Fernanda Candido
  • Daniel Costa Gonçalves do Vale;
  • Diogo Rodrigues Jimenes
  • Nilza Cristina Buttow
  • Carmem Patrícia Barbosa

Resumo

The obesity due to high caloric ingestion is related to the accumulation of body fat and
predisposes cardiovascular diseases. Recent studies about the High Intensity Interval Training
(HIIT) evidence benefits of its practice in patients that maybe carrying this disease, mainly
because of the reduction of comorbidities associated with obesity. This present study has the
objective of evaluating the HIIT effects on the adipocytes’ changes of the epicardium adipose
tissue in fat animals induced by the consumption of high-fat diet. It was used male rats of
Wistar lineage fed daily with HFD and trained by HIIT three times a week for 8 consecutive
weeks. The animals were weighted during the training sections and, after its euthanasia, were
realized histological analyses of the epicardium adipose tissue. The results showed that HFD
increased the body weight of the animals and the side view of the adipocytes. However, the
HIIT did not change the area of the adipocytes of the epicardial adipose tissue, even though
the diet had been a hypertrophy factor of this tissue. Then, we can conclude that HIIT
contributes to avoid the body weight gain but was not capable of reducing the area of the
adipocytes of the epicardium adipose tissue.

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Referências

World Health Organization. Obesity and Overweight, 9 June 2021.Available in
https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight. Accessed:
01 march 2023.
2. Bove AA. Exercise and Heart Disease. Methodist Debakey Cardiovasc J. 2016 Apr-
Jun;12(2):74-5. doi: https://doi.org/10.14797/mdcj-12-2-74. PMID: 27486487; PMCID:
PMC4969029.
3. Ansaldo AM, Montecucco F, Sahebkar A, Dallegri F, Carbone F. Epicardial adipose
tissue and cardiovascular diseases. Int J Cardiol. 2019 Mar 1;278:254-260. doi:
https://www.internationaljournalofcardiology.com/article/S0167-5273(18)33687-8/fulltext
4. Domínguez-Vías G, Segarra AB, Ramírez-Sánchez M, Prieto I. The Role of High Fat
Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance
in Wistar Rats. Nutrients. 2020 Feb 28;12(3):636. doi:
https://pubmed.ncbi.nlm.nih.gov/32121057/
5. Powers SK, Quindry JC, Kavazis AN. Exercise-induced cardioprotection against
myocardial ischemia-reperfusion injury. Free Radic Biol Med. 2008 Jan 15;44(2):193-
201. doi:
6. https://pubmed.ncbi.nlm.nih.gov/18191755/
7. Wewege M, van den Berg R, Ward RE, Keech A. The effects of high-intensity interval
training vs. moderate-intensity continuous training on body composition in overweight
and obese adults: a systematic review and meta-analysis. Obes Rev. 2017 Jun;18(6):635-
646. doi:
8. https://pubmed.ncbi.nlm.nih.gov/28401638/
9. Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity
continuous training: Superior metabolic benefits in diet-induced obesity mice. Life Sci.
2017 Dec 15;191:122-131. doi: https://pubmed.ncbi.nlm.nih.gov/28843495/
10. Jimenes DR, Teixeira Junior NR, Pereira AV, Berti JA, Barbosa CP, Sant'Ana DMG.
Human apoCIII transgenic mice with epicardial adipose tissue inflammation and
PRESERVATION of the cardiac plexus. Exp Gerontol. 2021 Jun;148:111261. doi:
https://www.sciencedirect.com/science/article/abs/pii/S053155652100036X?via%3Dihub
11. Suk M, Shin Y. Effect of high-intensity exercise and high-fat diet on lipid metabolism in
the liver of rats. J Exerc Nutrition Biochem. 2015 Dec 31;19(4):289-95. doi:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886838/
12. Tófolo LP, da Silva Ribeiro TA, Malta A, Miranda RA, Gomes RM, de Oliveira JC,
Abdennebi-Najar L, de Almeida DL, Trombini AB, da Silva Franco CC, Pavanello A,
Fabricio GS, Rinaldi W, Barella LF, de Freitas Mathias PC, Palma-Rigo K. Short-term
moderate exercise provides long-lasting protective effects against metabolic dysfunction

in rats fed a high-fat diet. Eur J Nutr. 2015 Dec;54(8):1353-62. doi:
https://pubmed.ncbi.nlm.nih.gov/25528242/
13. Estadella D, Oyama LM, Dâmaso AR, Ribeiro EB, Oller Do Nascimento CM. Effect of
palatable hyperlipidic diet on lipid metabolism of sedentary and exercised rats. Nutrition.
2004 Feb;20(2):218-24. doi: https://pubmed.ncbi.nlm.nih.gov/14962690/
14. Ghaben AL, Scherer PE. Adipogenesis and metabolic health. Nat Rev Mol Cell Biol. 2019
Apr;20(4):242-258. doi: https://www.nature.com/articles/s41580-018-0093-z
15. Mahajan R, Nelson A, Pathak RK, Middeldorp ME, Wong CX, Twomey DJ, Carbone A,
Teo K, Agbaedeng T, Linz D, de Groot JR, Kalman JM, Lau DH, Sanders P.
Electroanatomical Remodeling of the Atria in Obesity: Impact of Adjacent Epicardial Fat.
JACC Clin Electrophysiol. 2018 Dec;4(12):1529-1540. Doi:
https://pubmed.ncbi.nlm.nih.gov/30573116/
16. Rabkin SW, Campbell H. Comparison of reducing epicardial fat by exercise, diet or
bariatric surgery weight loss strategies: a systematic review and meta-analysis. Obes Rev.
Publicado
2023-05-11
Como Citar
1.
Candido F, Costa Gonçalves do Vale; D, Rodrigues Jimenes D, Cristina Buttow N, Patrícia Barbosa C. HIGH INTENSITY INTERVAL TRAINING DOES NOT CHANGE THE AREA IN THE ADIPOCYTES OF THE EPICARDIUM OF FAT RATS. arqmudi [Internet]. 11º de maio de 2023 [citado 28º de abril de 2024];27(ESPECIAL1). Disponível em: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/68226
Seção
4. Pharmacological and non-pharmacological interventions during critical phases