Silent myocardial ischemia in patients with diabetes mellitus type 2

Authors

  • V. I. Koshlia SE «Zaporizhzhia Medical Academy of Postgraduate Education of MOH Ukraine»,
  • A. V. Martynenko SE «Zaporizhzhia Medical Academy of Postgraduate Education of MOH Ukraine»,

DOI:

https://doi.org/10.14739/2310-1210.2015.6.56304

Keywords:

Myocardial Ischemia, Diabetes Mellitus Type 2, Holter Monitoring, Tomography

Abstract

Increased interest to the high prevalence of the phenomenon of silent myocardial ischemia was detected nowadays in the literature. Aim. To study role of the diabetes mellitus in the development of the silent myocardial ischemia. To underline main patophysiological features, diagnostic approaches and main streams in the treatment. Methods and results. Literature review of the Ukrainian and foreign issues.Results. Special place among the risk factors for CHD is type 2 diabetes takes silent myocardial ischemia. The prevalence of silent myocardial ischemia in patients with diabetes is significantly higher (2-7 times) than in those without diabetes. Many attribute this to the higher incidence of atherosclerosis and coronary heart disease in the general population in diabetic patients, but attention is drawn to a complication of diabetes - diabetic autonomic neuropathy, particularly cardiovascular its shape. Analysis of the literature showed that, despite the obvious successes in the study of  SMI, still remain differences in views on the possible causes and mechanisms of this phenomenon CHD.

Conclusion. The literature review provides information about the pathophysiological features of SMI in diabetes mellitus type 2, presented data on its prevalence, methods of diagnosis and treatment of the main directions reflected the prognostic significance of silent myocardial ischemia in patients with type 2 diabetes.

References

Skvorcov, Yu. I., Golovacheva, T. V., Skvorcov, V. V., & Skvorcov, K. Yu. (2011). O mekhanizmakh razvitiya bezbolevoj ishemii miokarda u bol'nykh sakharnym diabetom [About mechanisms of silent myocardial ischemia in patients with diabetes]. Poloklinika, 1, 29–32. [in Russian].

Bondar', I. A., Demin, A. A., & Shabelnikova, O.J. (2014). Sostoyanie serdca i sosudov pri cardiovaskulyarnoj forme avtonomnoj nejropatii u bol'nykh sakharnym diabetom 2 tipa [Condition of the heart and blood vessels in the form of cardiovascular autonomic neuropathy in patients with type 2 diabetes]. Sakharnyj diabet, 2, 41–43. [in Russian].

Dedov, I. I., Shestakova, M. V. (Eds.) (2015). Algoritmy specializirovannoj medicinskoj pomoshchi bol'nym sakharnym diabetom [Standards of specialized diabetes care]. Moscow. [in Russian].

Vertkin, A. L., Martynov, I. S., Gasilin, V. S., et al. (1995). Bezbolevaya ishemiya miokarda [Silent myocardial ischemia]. Moscow, Tetrafarm. [in Russian].

Okorokov, N. (2002). Diagnostika boleznej vnutrennikh organov [Diagnosis of diseases of the internal organs], (Vol. 6). Moscow: Medicinskaya literatura. [in Russian].

Lupanov, V. P., & Naumov, V. G. (2002). Bezbolevaya ishemiya miokarda: diagnostika i lechenie [Silent myocardial ischemia: diagnosis and treatment]. Serdce, 6, 276–282. [in Russian].

Volkov, V. I., Ermakovich, I. I., Strona, V. I. (2002). Nemaya ishemiya: osobennosti diagnostiki i lecheniya [Silent ischemia: Diagnosis and treatment]. Zdorov'e Ukrainy, 1. [in Ukrainian].

Alyokhin, M. N., Bozh′yev, A. M., & Morozova Yu. A. (2000). Vozmozhnosti stress-e′khokardiografii s tredmilom v ocenke bezbolevoj ishemii miokarda u bol'nykh ishemicheskoj bolezn'yu serdca [Features a treadmill stress echocardiography in the evaluation of silent myocardial ischemia in patients with coronary heart disease]. Kardiologiya, 11, 13–16. [in Russian].

Vertkin, A. L., Tkacheva, O. N., & Novikova, I. M. (2005). Bezbolevaya ishemiya i diabeticheskaya avtonomnaya nejropatiya [Silent ischemia and diabetic autonomic neuropathy]. Russkij medicinskij zhurnal, 13(15), 1036–1038. [in Russian].

Cohn, P. F., & Fox, K. M. (2003). Silent Myocardial Ischemia. Circulation, 108(10), 1263–1277. doi: 10.1161/01.CIR.0000088001.59265.EE.

Ilic, M., Ilic, S., Petrovic, D., et al. (2004). Silent myocardial ischemia in asymptomatic patients with multiple coronary risk factors. Medicine and Biology, 11(Suppl. 3), S107–112.

Xanthos, T., Ekmektzoglou, K., & Papadimitriou, L. (2008). Reviewing myocardial silent ischemia: Specific patient subgroups. International Journal of Cardiology, 124(2) 139–148.

Sajadieh, A., Nielsen, O., Rasmussen, V., Hein, H. O., & Hansen, J. F. (2005). Prevalence and prognostic significance of daily-life silent myocardial ischaemia in middle-aged and elderly subjects with no apparent heart disease. European Heart Journal, 26(14), 1402–1409. doi:10.1093/eurheartj/ehi169.

American Diabetes Association. (2010) Standards of Medical Care in Diabetes-2010. 2010. Diabetes Care, 33(1), S11–S61.

Langer, A., Freeman, M., Josse, R., Steiner, G., & Armstrong, P.W. (1991). Detection of silent myocardial ischemia in diabetes mellitus. The American Journal of Cardiology, 67, 1073–1078. doi:10.1016/0002-9149(91)90868-L.

Shakespeare, C. F., Katritsis, D., Crowther A., Cooper,I. C., Coltart, J. D., & Webb-Peploe, M. W. (1994). Differences in autonomic nerve function in patients with silent and symptomatic myocardial ischaemia. Br. Heart J., 71, 22–29. doi: 10.1136/hrt.71.1.22.

Manzella, D., & Paolisso, G. (2005). Cardiac autonomic activity and Type II diabetes mellitus. Clin. Sci., 108(2), 93–99. doi: 10.1042/CS20040223.

Vinik, A. I., Maser, R. E., Mitchell, B. D., & Freeman, R. (2003). Diabetic Autonomic Neuropathy. Diabetes Care, 26, 1553–1579. doi:10.2337/diacare.26.5.1553.

Zellweger, M. (2006). Prognostic Significance of Silent Coronary Artery Disease in Type 2 Diabetes. Herz Kardiovaskuläre Erkrankungen, 31(3), 240–245. doi: 10.1007/s00059-006-2790-1.

Bairey Merz, C. N., Olson, M. B., & Johnson, B. D., Bittner, V., Hodgson, T. K., Berga, S. L., et al. (2002). Women’s Ischemia Syndrome Evaluation. Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE). The American Journal of Medicine, 113(9), 723–727. doi: http://dx.doi.org/10.1016/S0002-9343(02)01366-9.

Choi, E., Chun, E., Choi, S., Chang, S. A., Choi, S. H., Lim, S., et al. (2009). Assessment of Subclinical Coronary Atherosclerosis in Asymptomatic Patients With Type 2 Diabetes Mellitus With Single Photon Emission Computed Tomography and Coronary Computed Tomography Angiography. The American Journal of Cardiology, 104(7), 890–896. doi: 10.1016/j.amjcard.2009.05.026.

Scognamiglio, R., Negut, C., Ramondo, A., Tiengo, A., & Avogaro, A. (2006). Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus. Journal of the American College of Cardiology, 47(1), 65–71. doi:10.1016/j.jacc.2005.10.008.

Bhalodkar, N., & Blum, S. (2004). Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects: Response to Wackers et al. Diabetes Care, 28(1), 231–232.

DeSliva, R. (2013). Heart disease. Santa Barbara. Calif.: Greenwood.

Koytak, P., Isak, B., Borucu, D., Uluc, K., Tanridag, T., & Us, O. (2011). Assessment of symptomatic diabetic patients with normal nerve conduction studies: Utility of cutaneous silent periods and autonomic tests. Muscle & Nerve, 43(3), 317–323. doi: 10.1002/mus.21877.

van Gilst, W. H., Warnica, J. W., Baillot, R., Johnstone, D., Calciu, C. D., Block, P., et al. (2006) Angiotensin–converting enzyme inhibition in patients with coronary artery disease and preserved left ventricular function: Ischemia Management with Accupril post–bypass graft via inhibition of angiotensin–converting enzyme (IMAGINE) compared with the other major trials in coronary artery disease. Am Heart J, 151, 1240–1246. doi: http://dx.doi.org/10.1016/j.ahj.2005.07.010.

Sejil, S., Janand-Delenne, B., Avierinos, J. F., Habib, G., Labastie, N., Raccah, D., et al. (2006) Six-year follow-up of a cohort of 203 patients with diabetes after screeningfor silent myocardial ischaemia. Diabet Med., 23(11), 1186–1191. doi: 10.1111/j.1464-5491.2006.01992.x.

How to Cite

1.
Koshlia VI, Martynenko AV. Silent myocardial ischemia in patients with diabetes mellitus type 2. Zaporozhye medical journal [Internet]. 2015Dec.29 [cited 2024Apr.20];17(6). Available from: http://zmj.zsmu.edu.ua/article/view/56304