Antioxidant and frigoprotective properties of glucosamine preparations and acetylsalicylic acid under conditions of acute local cold trauma

Authors

DOI:

https://doi.org/10.24959/ubphj.18.153

Keywords:

glucosamine hydrochloride, acetylsalicylic acid, cold trauma, hypothermia, lipid peroxidation, antioxidant system

Abstract

Topicality. Cold trauma (HT) is a common factor of the environmental impact on human body. They are found in all parts of our planet and in the structure of peacetime trauma are from 3 to 10 %, accompanied by significant disability of victims and mortality. Acute exposure to cold leads to increasing of free radicals formation, contributes to antioxidant system depletion (AOS) and activates lipid peroxidation (LPO).
Aim. To study the effect of glucosamine and acetylsalicylic acid (ASA) preparations on the course of experimental pathology (the state of the affected area of the skin, body temperature, body mass dynamics), the intensity of LPO and the state of AOS under conditions of model acute local CT (frostbite).
Materials and methods. As the frigoprotectors are selected G h/ch (Sigma-Aldrich, USA), “Glucosamine-S BHFZ” and the drug ASK (“Darnitsa”, Kiev). After a local CT, the rectal temperature, skin lesions, LPO and AOS in the blood serum were measured.
Results and discussion. G h/ch exhibits a more pronounced frigoprotective effect with local acute CT in terms of: skin lesions, restoration of rectal temperature and body weight, antioxidant effect, superior to ASA and Glucosamine-C BHPF.
Conclusions. The antioxidant properties of G h/ch, “Glucosamine-C BHFZ” and to a lesser extent ASA, which were detected in acute general cooling, are confirmed in this work under local CT conditions. These results substantiate the expediency of using these agents, primarily glucosamine, in the treatment of local cold trauma.

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Published

2018-03-14

Issue

Section

Pharmacology and biochemistry