17 articles in this issue
Carolyn M. Yrigollen and Beverly L. Davidson
Gene-editing using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is promising as a potential therapeutic strategy for many genetic disorders. CRISPR-based therapies are already being assessed in clinical trials, and evaluation of this...
Imama Naqvi, Emi Hitomi and Richard Leigh
Objective: To report a patient in whom an acute ischemic stroke precipitated chronic blood-brain barrier (BBB) disruption and expansion of vascular white matter hyperintensities (WMH) into regions of normal appearing white matter (NAWM) during the followi...
Lauren M. Schmitt, Rebecca C. Shaffer, David Hessl and Craig Erickson
Executive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic caus...
Balapal S. Basavarajappa and Shivakumar Subbanna
Rachel Michelle Saré, Christopher Figueroa, Abigail Lemons, Inna Loutaev and Carolyn Beebe Smith
James Adamson, Cansu Ozenc, Claire Baillie and Kate Tchanturia
Low self-esteem is a common feature in Anorexia Nervosa (AN) and has been hypothesised to act as a predisposing, precipitating, and perpetuating factor. The aim of this study was to assess the effectiveness of a Cognitive Behavioural Therapy (CBT)-based s...
Kristi L. Bartholomay, Cindy H. Lee, Jennifer L. Bruno, Amy A. Lightbody and Allan L. Reiss
Fragile X syndrome (FXS) is a genetic condition known to increase the risk of cognitive impairment and socio-emotional challenges in affected males and females. To date, the vast majority of research on FXS has predominantly targeted males, who usually ex...
Laith Thamer Al-Ameri, Talib Saddam Mohsin and Ali Tarik Abdul Wahid
Athanassios Protopapas and Rauno Parrila
We recently pointed out that there is no evidence to support the commonly held view that there is something wrong with the brains of children who have great difficulty learning to read. In response, it was argued that dyslexia should be considered to be a...
Valentina Pegoraro, Antonio Merico and Corrado Angelini
Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads, because of lower motor neuron involvement, to progressive muscle atrophy, weakness, ...
Brain Sciences Editorial Office
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Jana Nikitin and Alexandra M. Freund
Ioannis N. Mavridis
The nucleus accumbens (NA) and the cingulate gyrus (CG) are two vital limbic brain structures. They have attracted attention as deep brain stimulation (DBS) targets in the treatment of common refractory psychiatric illness. The primary purpose of this art...
Katherine C. Okoniewski, Anne C. Wheeler, Stacey Lee, Beth Boyea, Melissa Raspa, Jennifer L. Taylor and Donald B. Bailey, Jr.
Over the past 20 years, research on fragile X syndrome (FXS) has provided foundational understanding of the complex experiences of affected individuals and their families. Despite this intensive focus, there has been little progress on earlier identificat...
Rajesh Amerineni, Resh S. Gupta and Lalit Gupta
Two multimodal classification models aimed at enhancing object classification through the integration of semantically congruent unimodal stimuli are introduced. The feature-integrating model, inspired by multisensory integration in the subcortical superio...
John C. Crabbe, Pamela Metten, Antonia M. Savarese, Angela R. Ozburn, Jason P. Schlumbohm, Stephanie E. Spence and Wyatt R. Hack
Two independent lines of High Drinking in the Dark (HDID-1, HDID-2) mice have been bred to reach high blood alcohol levels after a short period of binge-like ethanol drinking. Male mice of both lines were shown to have reduced sensitivity to develop a tas...
Parminder J. S. Vig, Deyin Lu, Amber M. Paul, Ram Kuwar, Maria Lopez, Dobrivoje S. Stokic, A. Arturo Leis, Michael R. Garrett and Fengwei Bai
West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, includi...