30 articles in this issue
Sophie Preisker, Ann-Kathrin Brethack, Arne Bokemeyer, Dominik Bettenworth, Christian Sina and Stefanie Derer
Inflammatory bowel disease (IBD) is an umbrella term that comprises Crohn’s disease (CD) and ulcerative colitis (UC). Both entities are characterized by a disturbed mucosal immune response and an imbalance of intestinal microbiota composition. The c... see more
Sup Kim, Hyuk Soo Eun and Eun-Kyeong Jo
-
Adélia Mendes and Birthe Fahrenkrog
Sebastian Escobar-Aguirre, Duxan Arancibia, Amanda Escorza, Cristián Bravo, María Estela Andrés, Pedro Zamorano and Víctor Martínez
Takeshi Namekawa, Kazuhiro Ikeda, Kuniko Horie-Inoue and Satoshi Inoue
Various preclinical models have been developed to clarify the pathophysiology of prostate cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by DU-145, PC-3, and LNCaP cells, are useful tools to define mechanisms und... see more
Kara J. Turner, Vimal Vasu and Darren K. Griffin
Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to ... see more
Sarah Fischer, Ramesh Rijal, Peter Frommolt, Prerana Wagle, Roman Konertz, Jan Faix, Susanne Meßling and Ludwig Eichinger
Anna Signorile, Giuseppe Sgaramella, Francesco Bellomo and Domenico De Rasmo
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular localization, PHB1 and PHB2 have distinctive functions, but more evidence sugges... see more
Eva Žerovnik
Human stefin B is a protease inhibitor from the family of cystatins. It was reported that it forms oligomers in cells. We have shown that it has a role in cell’s response to misfolded proteins. We also have shown that its oligomers bind amyloid-beta... see more
Nadine A. Kerr, Juan Pablo de Rivero Vaccari, Oliver Umland, M. Ross Bullock, Gregory E. Conner, W. Dalton Dietrich and Robert W. Keane
Approximately 30% of traumatic brain injured patients suffer from acute lung injury or acute respiratory distress syndrome. Our previous work revealed that extracellular vesicle (EV)-mediated inflammasome signaling plays a crucial role in the pathophysiol... see more
Pei Chen, Zhipeng Lai, Yihui Wu, Lijun Xu, Xiaoxiao Cai, Jin Qiu, Panyang Yang, Meng Yang, Pan Zhou, Jiejie Zhuang, Jian Ge, Keming Yu and Jing Zhuang
Blue light is a major component of visible light and digital displays. Over-exposure to blue light could cause retinal damage. However, the mechanism of its damage is not well defined. Here, we demonstrate that blue light (900 lux) impairs cell viability ... see more
Bertrand Daignan-Fornier and Benoît Pinson
Alicja M. Gruszka, Debora Valli, Cecilia Restelli and Myriam Alcalay
Cell adhesion is a process through which cells interact with and attach to neighboring cells or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an important role in normal haematopoiesis and in acute myeloid leukaemia (AML).... see more
Dar-Shong Lin, Yu-Wen Huang, Che-Sheng Ho, Pi-Lien Hung, Mei-Hsin Hsu, Tuan-Jen Wang, Tsu-Yen Wu, Tsung-Han Lee, Zo-Darr Huang, Po-Chun Chang and Ming-Fu Chiang
Dysfunction of mitochondria causes defects in oxidative phosphorylation system (OXPHOS) and increased production of reactive oxygen species (ROS) triggering the activation of the cell death pathway that underlies the pathogenesis of aging and various dise... see more
Giuseppe Caruso, Claudia G. Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona F. Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria A. Sortino, Susan M. Lunte and Filippo Caraci
Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of... see more
Quante Singleton, Kumar Vaibhav, Molly Braun, Chandani Patel, Andrew Khayrullin, Bharati Mendhe, Byung R. Lee, Ravindra Kolhe, Helen Kaiser, Mohamed E. Awad, Tunde Fariyike, Ranya Elsayed, Mohammed Elsalanty, Carlos M. Isales, Yutao Liu, Mark W. Hamrick, Krishnan M. Dhandapani and Sadanand Fulzele
Traumatic brain injury (TBI) is a major source of worldwide morbidity and mortality. Patients suffering from TBI exhibit a higher susceptibility to bone loss and an increased rate of bone fractures; however, the underlying mechanisms remain poorly defined... see more
Yongjie Xu, Wei Wu, Qiu Han, Yaling Wang, Cencen Li, Pengpeng Zhang and Haixia Xu
The emerging data indicates that non-coding RNAs (ncRNAs) epresent more than the “junk sequences” of the genome. Both miRNAs and long non-coding RNAs (lncRNAs) are involved in fundamental biological processes, and their deregulation may lead t... see more
Tien-An Lin, Victor Chien-Chia Wu and Chao-Yung Wang
Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activatio... see more
Cells Editorial Office
Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Nihar J. Mehta, Praneet Kaur Marwah and David Njus
Parkinson’s disease, like other neurodegenerative diseases, exhibits two common features: Proteinopathy and oxidative stress, leading to protein aggregation and mitochondrial damage respectively. Because both protein aggregates and dysfunctional mit... see more
Petra Procházková Schrumpfová, Miloslava Fojtová and Jirí Fajkus
Miriam Sarah Weber, Matthias Wojtynek and Ohad Medalia
The architecture of protein assemblies and their remodeling during physiological processes is fundamental to cells. Therefore, providing high-resolution snapshots of macromolecular complexes in their native environment is of major importance for understan... see more
Katleen Frauz, Luis Felipe R. Teodoro, Giane Daniela Carneiro, Fernanda Cristina da Veiga, Danilo Lopes Ferrucci, André Luis Bombeiro, Priscyla Waleska Simões, Lúcia Elvira Alvares, Alexandre Leite R. de Oliveira, Cristina Pontes Vicente, Rui Seabra Ferreira, Benedito Barraviera, Maria Esméria C. do Amaral, Marcelo Augusto M. Esquisatto, Benedicto de Campos Vidal, Edson Rosa Pimentel and Andrea Aparecida de Aro
Marianna Penzo, Lorenzo Montanaro, Davide Treré and Massimo Derenzini
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: (1) allowed the understanding of the r... see more
Jun Liu, Lihui Wang, Zhiguo Wang and Jun-Ping Liu
Sarka Jelinkova, Petr Fojtik, Aneta Kohutova, Aleksandra Vilotic, Lenka Marková, Martin Pesl, Tereza Jurakova, Miriama Kruta, Jan Vrbsky, Renata Gaillyova, Iveta Valášková, Ivan Frák, Alain Lacampagne, Giancarlo Forte, Petr Dvorak, Albano C. Meli and Vladimir Rotrekl
Recent data on Duchenne muscular dystrophy (DMD) show myocyte progenitor’s involvement in the disease pathology often leading to the DMD patient’s death. The molecular mechanism underlying stem cell impairment in DMD has not been described. We... see more
Alessio Squassina, Claudia Pisanu and Roberta Vanni
Mood disorders are associated with an increased risk of aging-related diseases, which greatly contribute to the excess morbidity and mortality observed in affected individuals. Clinical and molecular findings also suggest that mood disorders might be char... see more
Jéssica dos Santos Parisi, Mab Pereira Corrêa and Cristiane Damas Gil
Annexin A1 (AnxA1) is a protein with potent anti-inflammatory actions and an interesting target that has been poorly explored in skin inflammation. This work evaluated the lack of endogenous AnxA1 in the progression of ovalbumin (OVA)-induced atopic derma... see more
Xiaoxu Li, Salman Ahmad, Akhtar Ali, Cun Guo, Hong Li, Jing Yu, Yan Zhang, Xiaoming Gao and Yongfeng Guo
Serena Saladini, Michele Aventaggiato, Federica Barreca, Emanuela Morgante, Luigi Sansone, Matteo A. Russo and Marco Tafani
Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour cells are addicted to glutamine and often show an overexpression of gluta... see more