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55  Articles
1 of 7 pages  |  10  records  |  more records»
Two series of new 3,5-disubstituted-pyrazole-1-carbothioamides (4a-f and 5a-e) were designed and synthesized through condensation reaction between chalcones and thiosemicarbazides under alkaline condition via cyclocondensation reaction. The structures hav... see more

Bisphosphonates remain one of the most effective drugs to treat diseases of the musculoskeletal system. Among a wide range of possibleoptions, the methods of bioinformatic analysis were developed, selected and synthesized analogs of bisphosphonates, the r... see more

Conclusions. It has been found that the reactions of 1,3-diaryl substituted pyrazole-4-carbaldehydes with 3-methyl-5-aminopyrazole and 2,2-dimethyl-1,3-dioxane-4,6-dione are regioselective and lead to the formation of pyrazolo[3,4-b]pyridone systems. This... see more

A library of some novel classes of pyrano[2,3-c]pyrazole-3-carboxylates was synthesized by employing uncatalyzed domino four-component reaction using diethyloxaloacetate, hydrazine hydrate, aldehydes and malononitrile in refluxing of ethanol-acetic acid s... see more

A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation re... see more

Possible structures of imidazole, pyrazole, and their semi saturated and fully saturated derivatives have been studied at the DFT and ab initio computational levels. Calculations have been performed using several computational schemes (BLYP, PBE0, CAM-B3L... see more

We describe a one-pot four component synthesis of pyrano[2,3-c]pyrazoles from hydrazine hydrate or phenyl hydrazine, ethyl acetoacetate, an aldehyde, and malononitrile in the presence of catalytic amounts of a caffeine as a green catalyst in water at 50 º... see more

The regulating activity of new synthetic low molecular weight heterocyclic compounds, pyrazole derivatives on morphometric, and biochemical parameters of wheat (Triticum aestivum L.) seedlings was studied. The synthetic compounds used at the concentration... see more

A series of tetrasubstituted pyrazole-3-carboxamides (3a–c) and pyr­azole-3-carbonyl thioureides (6a–c) were synthesized and their structures char­ac­terized by IR, NMR and elemental analysis. The antibacterial potential against specific Gram-positive and... see more

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