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91  Articles
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Hyperthyroidism is considered to be an emergency in children. Death can occur in 10-20% of cases. This condition is found more often in adolescents and girls. Cholestasis may be caused by the hyperthyroidism or side effects of anti-thyroid drugs. Increase... see more

Objective. We describe a rare case of pseudohyponatremia in the setting of hypercholesterolemia caused by cholestasis due to metastatic liver disease and provide a review of the published cases in the literature.Case Report. We report a case of pseudohypo... see more

Objective. Comparative studying of levels of some biochemical indices in experimental acute biliary pancreatitis and obstructive cholestasis.Materials and methods. An acute biliary pancreatitis was simulated on 32 rats and obstructive cholestasis – on 23.... see more

Biliary atresia (BA) is extrahepatic cholestasis that result death within the first 2 years if the diagnosis and intervention are delayed. Etiology and pathogenesis of  BA is still uncertain. Viral infections are thought to be one of the causes, incl... see more

Intrahepatic cholestasis of pregnancy (ICP) is a complex disease described by pruritus connected with elevated serum bile acid or amino transferase level. Usually,it occurs to the third trimester of pregnancy and improves itself after delivery.In 1970’s t... see more

Neonatal cholestasis due to citrin deficiency is an autosomal recessive metabolic disorder caused by mutations in SLC25A13 gene. Mutations in this gene have a relatively high prevalence in East-Asian races compared to European or Afro-Caribbean races. Mut... see more

Intrahepatic cholestasis of pregnancy (ICP) is cholestasis condition characterized by pruritus, elevated serum aminotransferase and bile acid levels with onset in the second or third trimester of pregnancy. Estimated of ICP prevalence only 0.001% to 0.3%.... see more

Objective.To investigate the impact of decompression of biliary ducts towards the bile production and excretion hepatic function after experimental cholestasis of different duration.??terials and methods. In experiment on nonline white rats the obturation... see more

BACKGROUND: Cholestasis caused by obstruction of the common bile duct and may developed gut-derived sepsis due to reactive oxygen species (ROS) accumulation. Ursodeoxycholic acid (UDCA) and glutathione are widely known for their antioxidant properties, th... see more

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