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4.394  Articles
1 of 440 pages  |  10  records  |  more records»
Background: Resveratrol, a well-known natural compound and nutrient, activates the deacetylation ability of SIRT1, demonstrating p53-dependent apoptosis functions in many diseases. However, the nascent proteomic fluctuation caused by resveratrol is s... see more

In vivo, folding of many proteins occurs during their synthesis in the ribosomeand continues after they have escaped from the ribosomal exit tunnel. Inthis research, we investigate the confinement effects of the ribosome on thecotranslational folding of t... see more

Protein secretion in general depends on signal sequence (also named leader sequence), a hydrophobic segment located at or close to the NH2-terminus of a secretory or membrane protein. This sequence guides the entry of nascent polypeptides into the lumen o... see more

In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the sum of transcription, mRNA degradation and protein degradation. Therefore, it is essential to inv... see more

Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis. Although MMPs were originally identified as matrixin proteases... see more

Em um de seus ensaios feministas entitulado Um teto todo seu (1929), Virginia Woolf (1882-1941) questiona a aparente ausência de mulheres escritoras no Renascimento inglês. A indagação de Woolf é pertinente, uma vez que a literatura masculina era, irrefut... see more

Red blood cells (RBC) are the major cell component of blood. Their main function is to transport oxygen and carbon dioxide, however, besides the main function of RBCs have also the ability to transport immune complexes, express numerous adhesion molecules... see more

Plants respond to pest attack, among other mechanisms, by producing specific proteins with insecticidal properties. Proteins with toxic effects on insects have also been discovered in many other organisms, especially fungi and bacteria. Due to their biolo... see more

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