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1.810.939  Articles
1 of 181.095 pages  |  10  records  |  more records»
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway and an abundance of different others, e.g., Akt signaling, NF-κB signaling,... see more

Non-neuronal acetylcholine plays a substantial role in the human skin by influencing adhesion, migration, proliferation and differentiation of keratinocytes. These processes are regulated by the Mitogen-Activated Protein (MAP) kinase cascade. Here we show... see more

AGC kinases are highly conserved regulators in a variety of cellular processes such as differentiation, proliferation, and growth.  They are known to play important roles in stress and hormonal responses, including ROS signaling. AGC kinases are the ... see more

The Pim-1 enzyme from the serine/threonine protein kinase family is a likely target for the targeted therapy of tumors of hematopoietic and lymphoid tissues. Triazolopyridine is an universal scaffold upon which international scientific programs have been ... see more

Paper description:Rubus chingii Hu possesses antioxidant, anti-inflammatory and anti-aging activities.The ethanol extract of the fruit (E-EA) demonstrated significant anti-photoaging properties in UVB-induced human fibroblast (HFF-1) cells, observed as a ... see more

Diabetes mellitus (DM) causes multiple dysfunctions including circulatory disorders such as cardiomyopathy, angiopathy, atherosclerosis and arterial hypertension. Moreover, DM can strongly affect pulmonary circulation, enhancing the wall thickness of the ... see more

Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive cogni... see more

Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt) are observed with high frequency during malignant transformation and cancer progression. Oncogenic gene mutations coding for the upstream regulators or Akt, e.g.... see more

The mangosteen pericarp contains a class of compounds called xanthones, including a-mangostin, ß-mangostin, and, ?-mangostin. Mangosteen products have become popular natural medicine. cancer is a malignant tumor types are particularly deadly caused by pro... see more

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