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53.731  Articles
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Topicality. Insufficient light in the world scientific literature the problem of changing the regulatory mechanisms of the immune response depending on age. Little-studied molecular events and cellular interactions underlying the mechanisms of immunoreact... see more

In the article the results of experimental studies aimed at identifying of sensitizing and allergenic properties of polyols oral intake of warm-blooded animals. The task of the research stage to assess skin-resorptive action alternative was to obtain answ... see more

Topicality. Insufficient light in the world scientific literature the problem of changing the regulatory mechanisms of the immune response depending on age. Little-studied molecular events and cellular interactions underlying the mechanisms of immunoreact... see more

Laboratory is the main supporting to reach the learning aim that appropriate competency for Nutrition Department students. Utilization of experimental animals as objects experiment in the laboratory to test in vivo ( laboratory with experimental animals )... see more

Objective of the study was to determine the placenta cryoextract impact on the restoration of the morphofunctional ability of the BALB/c mice uterus and ovaries after modeling their premature ovarian failure syndrome (POF) in the experiment.Materials and ... see more

Liver cirrhosis is one of the acute problems of modern hepatology that develops in case of long-term chronic hepatitis. It is known that cytokines play an important role in controlling an adaptive response to chronic toxic damage.After the morphological e... see more

Bagmut I. Yu., Popova T. M., Titkova A. V., Philipchenko S. M., Shepylieva N. V. The influence of sub-toxic dose xenobiotic on immune response of experimental animals = ????? ???????????? ??? ????????????? ?? ?????? ????????? ? ????????????????? ?????? = ... see more

The aim of work was to make biochemical investigations for detection of pro-oxidant and antioxidant systems markers in guinea pigs` bronchi before and after treatment of thiotriazolin during experimental allergic alveolitis development. Gradual elevation ... see more

EFECTO DEL D-004, SAW PALMETTO, Y TAMSULOSIN SOBRE LA APOPTOSIS EN LA HIPERPLASIA PROSTÁTICA INDUCIDA EN RATAS / EFFECT OF D-004, SAW PALMETTO, AND TAMSULOSIN ON APOPTOSIS IN INDUCED PROSTATIC HYPERPLASIA IN RATS EFECTO DEL D-004, SAW PALMETTO, Y TAMSULOSIN SOBRE LA APOPTOSIS EN LA HIPERPLASIA PROSTÁTICA INDUCIDA EN RATAS / EFFECT OF D-004, SAW PALMETTO, AND TAMSULOSIN ON APOPTOSIS IN INDUCED PROSTATIC HYPERPLASIA IN RATSObjetivo: Evaluar el efecto del D-004, Saw Palmetto (SP) y Tamsulosin, sobre la apoptosis, en la hiperplasia de próstata inducida por testosterona y por fenilefrina en ratas.Materiales y métodos: se estudiaron 2 series experimentales para inducir hiperplasia prostática (HP). En la serie1 se indujo la HP con testosterona. Las ratas se distribuyeron en 6 grupos: control negativo y positivo, 3 grupos tratados con D004 a las dosis de 200, 400 y 800 mg/kg, y otro de SP (400 mg/kg). En la serie 2 se administró fenilefrina. Se estudiaron 5 grupos: un control negativo, un control positivo, un grupo D-004 y SP (400mg/kg) y Tamsulosin(0.4mg/kg). Las muestras de próstata ventral se procesaron para el estudio inmunohistoquímico de apoptosis. El indice apoptótico (IA) se analizó como variable de eficacia primaria.Resultados: en los controles positivos de las series 1 y 2 se observó disminución significativa del IA, vs los controles negativos. En la serie1, las muestras de los animales tratados con D-004, así como con SP mostraron aumento significativo de los IA, vs control positivo, al igual que en la serie 2, los tratados con D-004 y SP mostraron aumento significativo de los IA vs control positivo, al igual que las de Tamsulosín.Conclusiones: El D-004 previno la disminuciónde la apoptosis inducida por T y FE en ratas, al igual que el SP, lo que permite relacionar por primera vez su efecto sobre la HP con su efecto inductor de la apoptosis. El Tamsulosin produjo menor efecto.AbstractObjective: To evaluate the effect of D-004, Saw Palmetto (SP) and Tamsulosin, on apoptosis, in prostatic hyperplasia induced by testosterone and phenylephrine in rats.Material and methods: Two experimental series were studied for induction of prostatic hyperplasia (PH). In serie1 PH was induced by testosterone. Rats were distributed in 6 groups: negative and positive controls, 3 groups treated with D004 at doses of 200, 400 and 800 mg/kg, and other of SP (400 mg/kg). In serie 2 phenylephrine was administered. Five groups were studied: negative and positive control, D-004 and SP (400mg/kg) and Tamsulosin (0.4mg/kg). Samples of ventral prostate were processed for immunohistochemical study of apoptosis. The apoptotic index (AI) was analyzed as the primary efficacy variable.Results: In positive controls of series 1 and 2, a significative reduction of AI was observed vs negative controls. In serie1, samples of treated animals with D-004, and SP showed significative elevation of AI, vs positive control, as in serie 2, D-004 and SP treated groups showed significative elevation of AI vs positive control, as in Tamsulosin group.Conclusions: D-004 prevented the reduction of induced apoptosis by T and FE in rats, as same of SP, and may possible to relate at first, its effect on HP with apoptosis induction effect. Tamsulosin showed a lesser effect.

(0.4mg/kg). Las muestras de próstata ventral se procesaron para el estudio inmunohistoquímico de apoptosis. El indice apoptótico (IA) se analizó como variable de eficacia primaria.Resultados: en los controles positivos de las series 1 y 2 se observó dismi... see more

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