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KAROTENOID DARI MAKROALGAE DAN MIKROALGAE: POTENSI KESEHATAN APLIKASI DAN BIOTEKNOLOGI [Carotenoids from Macroalgae and Microalgae: Health Potential, Application and Biotechnology] Helly de Fretes1)*, AB. Susanto2), Budhi Prasetyo1) dan Leenawaty Limantara3) 1) Magister Biologi, Universitas Kristen Satya Wacana, Salatiga 2) Fakultas Perikanan dan Ilmu Kelautan, Universitas Diponegoro, Tembalang, Semarang 3) Ma Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Malang   Diterima 13 Desember 2011 / Disetujui 24 Mei 2012 SUMMARY   Algae, both micro and macroalgae, is one of the largest producers of carotenoids. The major composition of carotenoid on algae are ß-carotene, astaxanthin, luthein, zeaxanthin, cryptoxanthin, and fucoxanthin which have important roles for human health. Carotenoids were produced by several microalgae species such as Dunaliella sallina, Haemotococcus pluvialis, Chlorella pyrenoidosa, Spirulina platensis, Nannnochloropsis oculata, and also from some macroalgae species such as Kappaphycus alvarezii, Sargassum sp, and Caulerpa sp. Carotenoids from algae has been proven as a powerful antioxidant and may prevent some degenerative diseases, cardiovascular, and cancer. Carotenoid also has been applied as a natural dye and dietary supplements. Biotechnology has been developed to increase the production of carotenoids from micro- and macroalgae. The large-scale cultivation of microalgae, either in open or closed system are shown to increase carotenoid production. During cultivation, some stress conditions can be specifically manipulated to optimize carotenoid production from microalgae.   Keywords: application, biotechnology, carotenoid, macroalgae, microalgae SUMMARY   Algae, baik mikro maupun makroalgae, merupakan salah satu penghasil karotenoid terbesar. Komposisi karotenoid penting yang dikandung oleh mikroalgae dan makroalgae terdiri dari ß-karoten, astaxantin, lutein, zeaxantin, kriptoxantin, serta fukoxantin.Seluruhnya memiliki peranan bagi kesehatan manusia. Karotenoid-karotenoid tersebut diproduksi oleh beberapa spesies mikroalga yaitu Dunaliella sallina, Haemotococcus pluvialis, Chlorella pyrenoidosa, Anthrospira platensis, serta Nannnochloropsis oculata, dan juga beberapa spesies makroalga seperti Kappaphycus alvarezii, Sargassum sp, dan Caulerpa sp. Karotenoid dari algae telah terbukti sebagai antioksidan yang kuat serta dapat mencegah beberapa penyakit degeneratif, kardiovaskular, dan kanker. Karotenoid juga telah diaplikasikan sebagai pewarna dan suplemen makanan. Bioteknologi telah dikembangkan dalam rangkai peningkatan produksi karotenoid dari mikroalgae dan makroalgae. Selama kultivasi, beberapa kondisi stres dapat dimanipulasi secara khusus untuk mengoptimalkan produksi karotenoid dari mikroalgae.   Kata kunci: aplikasi, bioteknologi, karotenoid, makroalgae, mikroalgae

KAROTENOID DARI MAKROALGAE DAN MIKROALGAE: POTENSI KESEHATAN APLIKASI DAN BIOTEKNOLOGI [Carotenoids from Macroalgae and Microalgae: Health Potential, Application and Biotechnology] Helly de Fretes1)*, AB. Susanto2), Budhi Prasetyo1) dan Leenawaty Limantar... see more
KAROTENOID DARI MAKROALGAE DAN MIKROALGAE: POTENSI KESEHATAN APLIKASI DAN BIOTEKNOLOGI [Carotenoids from Macroalgae and Microalgae: Health Potential |  Application and Biotechnology] Helly de Fretes1)* |  AB. Susanto2) |  Budhi Prasetyo1) dan Leenawaty Limantara3) 1) Magister Biologi |  Universitas Kristen Satya Wacana |  Salatiga 2) Fakultas Perikanan dan Ilmu Kelautan |  Universitas Diponegoro |  Tembalang |  Semarang 3) Ma Chung Research Center for Photosynthetic Pigments |  Universitas Ma Chung |  Malang   |  Diterima 13 Desember 2011 / Disetujui 24 Mei 2012 SUMMARY   |  Algae |  both micro and macroalgae |  is one of the largest producers of carotenoids. The major composition of carotenoid on algae are ß-carotene |  astaxanthin |  luthein |  zeaxanthin |  cryptoxanthin |  and fucoxanthin which have important roles for human health. Carotenoids were produced by several microalgae species such as Dunaliella sallina |  Haemotococcus pluvialis |  Chlorella pyrenoidosa |  Spirulina platensis |  Nannnochloropsis oculata |  and also from some macroalgae species such as Kappaphycus alvarezii |  Sargassum sp |  and Caulerpa sp. Carotenoids from algae has been proven as a powerful antioxidant and may prevent some degenerative diseases |  cardiovascular |  and cancer. Carotenoid also has been applied as a natural dye and dietary supplements. Biotechnology has been developed to increase the production of carotenoids from micro- and macroalgae. The large-scale cultivation of microalgae |  either in open or closed system are shown to increase carotenoid production. During cultivation |  some stress conditions can be specifically manipulated to optimize carotenoid production from microalgae.   |  Keywords: application |  biotechnology |  carotenoid |  macroalgae |  microalgae SUMMARY   |  Algae |  baik mikro maupun makroalgae |  merupakan salah satu penghasil karotenoid terbesar. Komposisi karotenoid penting yang dikandung oleh mikroalgae dan makroalgae terdiri dari ß-karoten |  astaxantin |  lutein |  zeaxantin |  kriptoxantin |  serta fukoxantin.Seluruhnya memiliki peranan bagi kesehatan manusia. Karotenoid-karotenoid tersebut diproduksi oleh beberapa spesies mikroalga yaitu Dunaliella sallina |  Haemotococcus pluvialis |  Chlorella pyrenoidosa |  Anthrospira platensis |  serta Nannnochloropsis oculata |  dan juga beberapa spesies makroalga seperti Kappaphycus alvarezii |  Sargassum sp |  dan Caulerpa sp. Karotenoid dari algae telah terbukti sebagai antioksidan yang kuat serta dapat mencegah beberapa penyakit degeneratif |  kardiovaskular |  dan kanker. Karotenoid juga telah diaplikasikan sebagai pewarna dan suplemen makanan. Bioteknologi telah dikembangkan dalam rangkai peningkatan produksi karotenoid dari mikroalgae dan makroalgae. Selama kultivasi |  beberapa kondisi stres dapat dimanipulasi secara khusus untuk mengoptimalkan produksi karotenoid dari mikroalgae.   |  Kata kunci: aplikasi |  bioteknologi |  karotenoid |  makroalgae |  mikroalgae

PENGHAMBAT a AMILASE: JENIS, SUMBER, DAN POTENSI PEMANFAATANNYA DALAM KESEHATAN [a Amylase Inhibitors: Types, Sources, and Their Potential Utilization for Health Purposes] Budiasih Wahyuntari* Laboratoria Pengembangan Teknologi Industri Agro-Biomedika (LA... see more
< | p class="MsoNormal" style="text-align:center | " align="center"> | < | strong> | < | span style="font-size:13pt | " lang="de" xml:lang="de"> | PENGHAMBAT a AMILASE: JENIS |  SUMBER |  DAN POTENSI PEMANFAATANNYA< | /span> | < | /strong> | < | /p> |  < | p class="MsoNormal" style="text-align:center | " align="center"> | < | strong> | < | span style="font-size:13pt | " lang="de" xml:lang="de"> | DALAM KESEHATAN< | /span> | < | /strong> | < | /p> |  < | p class="MsoNormal" style="margin-top:18pt | text-align:center | " align="center"> | < | span style="font-size:12pt | " lang="in" xml:lang="in"> | [< | /span> | < | span style="font-size:12pt | " lang="de" xml:lang="de"> | a Amylase Inhibitors: Types |  Sources |  and Their Potential Utilization for Health Purposes< | /span> | < | span style="font-size:12pt | " lang="in" xml:lang="in"> | ]< | /span> | < | /p> |  < | p class="MsoNormal" style="margin-top:18pt | text-align:center | " align="center"> | < | strong> | < | span lang="de" xml:lang="de"> | Budiasih Wahyuntari< | /span> | < | /strong> | < | strong> | < | span lang="in" xml:lang="in"> | *< | /span> | < | /strong> | < | /p> |  < | p class="MsoNormal" style="margin-top:6pt | text-align:center | " align="center"> | < | span style="font-size:10pt | " lang="de" xml:lang="de"> | Laboratoria Pengembangan Teknologi Industri Agro-Biomedika (LAPTIAB) |  Badan Pengkajian dan Penerapan Teknologi |  Kawasan Pusat Teknologi dan Ilmu Pengetahuan (PUSPIPTEK) gedung no 610 |  Serpong |  Tangerang 15310< | /span> | < | /p> |  < | p class="MsoNormal" style="text-align:center | " align="center"> | < | span style="font-size:10pt | " lang="in" xml:lang="in"> |   | < | /span> | < | /p> |  < | p class="MsoNormal" style="text-align:center | " align="center"> | < | span style="font-size:9pt | "> | Diterima < | /span> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> | 09< | /span> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> |  < | /span> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> | Desember< | /span> | < | span style="font-size:9pt | "> |  200< | /span> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> | 9< | /span> | < | span style="font-size:9pt | "> |  / Disetujui 19 Desember 201< | /span> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> | 1< | /span> | < | strong> | < | /strong> | < | /p> |  < | p class="MsoNormal" style="margin:18pt 0cm .0001pt 27pt | text-align:center | " align="center"> | < | strong> | < | em> | < | span style="font-size:12pt | " lang="de" xml:lang="de"> | SUMMARY< | /span> | < | /em> | < | /strong> | < | /p> |  < | p class="MsoNormal" style="text-indent:14.2pt | "> | < | em> | < | span style="font-size:10pt | " lang="in" xml:lang="in"> |   | < | /span> | < | /em> | < | /p> |  < | p class="MsoNormal" style="text-indent:14.2pt | "> | < | em> | < | span style="font-size:9pt | "> | Alpha amylase inhibitors affect carbohydrate metabolism in digestive system. The inhibitors induce carbohydrate tolerance |  fullness and prolonging gastric emptying that might be used to aid in diabetic and obesity treatment. There are two types of < | /span> | < | /em> | < | span style="font-size:9pt | "> | a< | /span> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> | -< | /span> | < | em> | < | span style="font-size:9pt | "> |  amylase inhibitors |  proteinaceous and non-proteinaceous ones. Proteinaceous inhibitor is classified into seven classes including legumes |  lectin |  knottin |  cereal |  Kunitz |  < | /span> | < | /em> | < | em> | < | span style="font-size:9pt | font-family:Symbol | "> | < | span> | g< | /span> | < | /span> | < | /em> | < | em> | < | span style="font-size:9pt | "> | -thionin and thaumatin types. Plant proteinaceous inhibitors are present in cereals and legumes. Some non-proteinaceous inhibitors include flavonid |  polyphenols |  organic acid that might be produced by microbes or extracted from plants such as acarbose |  saponin dan cardiac glycoside |  gallic acid |  proto-catechuic acid |  caffeic acid |  ellagic acid |  ferulic acid |  quercetin hibiscus acid and < | /span> | < | /em> | < | span style="font-size:9pt | "> | a- |  ß- and ?-cyclodextrin.< | /span> | < | em> | < | /em> | < | /p> |  < | p class="MsoNormal" style="text-indent:14.2pt | "> | < | em> | < | span style="font-size:9pt | " lang="in" xml:lang="in"> | < | span> |   | < | /span> | < | /span> | < | /em> | < | em> | < | /em> | < | /p> |  < | p class="MsoNormal"> | < | strong> | < | em> | < | span style="font-size:9pt | " lang="de" xml:lang="de"> | Key words:< | /span> | < | /em> | < | /strong> | < | em> | < | span style="font-size:9pt | " lang="de" xml:lang="de"> |  inhibitor amylase |  anti obesity |  diabetes< | /span> | < | /em> | < | em> | < | /em> | < | /p> | 

This study aims to determine the potential of the Cissus quadrangularis extract to decreased the expression of IL-1 ß so that it can to inhibit bone resorption and osteoporosis fracture healing is not delayed union. Forty rats adapted for 1 week... see more

Full-thickness wound healing is a complex process requiring a well-orchestrated mechanism of various factors, including cytokines, particularly interleukin (IL)-10 and transforming growth factor (TGF)-ß. IL-10 and TGF-ß act as robust anti-inflammatory cyt... see more

The main focus of the article is the problem of neonatal pneumonia diagnosis. Its aim is to examine the state of inborn immunity among mature newborns with pneumonia in terms of TLR2, interleukins 1 ß and 10. In the course of the research we have examined... see more

BACKGROUND: Mesenchymal stem cells (MSCs) may serve as immunoregulators by producing various anti-inflammatory molecules. Under sufficient level of TNF-a, MSCs become activated and adopt immune-suppressive phenotype (MSCs type-2) by releasing various anti... see more

Interacciones farmacocinéticas de la azitromicina e implicación clínica Interacciones farmacocinéticas de la azitromicina e implicación clínicaIntroducción: El síndrome respiratorio agudo grave (por la COVID-19) es en la actualidad la primera causa de muerte en el Perú, por lo que se requiere de fármacos eficaces y seguros para mitigar la enfermedad. Se realizó una búsqueda bibliográfica en SciELO y PubMed/ Medline; se seleccionaron 37 de 58 artículos sobre el tema.Objetivos: Revisar e integrar la información sobre las interacciones farmacocinéticas de la azitromicina que se prescriben en el tratamiento ambulatorio de la COVID-19 en el Perú, y evaluar su implicación clínica.Desarrollo: La azitromicina es usada en la COVID-19, por su actividad antiinflamatoria, al inhibir a las interleucinas (IL1, 6, 8 y TNF-a), y a las moléculas de adhesión intracelular 1 (ICAM1); y por inducir la producción de interferón tipo I (IFN-a, IFN-ß) y III (IFN-?) en células de pacientes con enfermedad pulmonar obstructiva crónica. Los estudios de tres brazos, aleatorizado y abierto, indican que la azitromicina no genera cambios en los parámetros farmacocinéticos de la ivermectina, sildenafilo, rupatadina y desloratadina; los estudios de un solo centro, abierto, sin ayuno y de dos períodos, evidencian que la azitromicina influye en los parámetros farmacocinéticos de venetoclax y de los psicotrópicos.Conclusiones: Basado en la evidencia de los estudios clínicos revisados e integrados, se concluye que estas son limitadas y de poca relevancia clínica, sin embargo, se propone usar el antibiótico bajo el criterio científico del médico, para evitar las interacciones farmacocinéticas y las reacciones adversas de los fármacos.

Objetivos: Revisar e integrar la información sobre las interacciones farmacocinéticas de la azitromicina que se prescriben en el tratamiento ambulatorio de la COVID-19 en el Perú, y evaluar su implicación clínica.Desarrollo: La azitromicina es u... see more

Objectives: To study the effect of ultrashort wave combined with loxoprofen sodium on serum inflammatory factors in patients with acute gouty arthritis.Methods: Records of patients with acute gouty arthritis who were treated in The Fourth Hospital of Chan... see more

Introduction.    Among surgical diseases, peritonitis is a life-threatening pathological condition characterized by inflammation at both local and systemic levels [8]. Identifying proinflammatory mediators in peripheral blood and in periton... see more

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