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4.816  Articles
1 of 483 pages  |  10  records  |  more records»
Micronuclei are small, aberrant nuclear compartments containing mis-segregated chromosomes or chromosomal fragments. During telophase, dysfunctional micronuclear envelope reassembly leaves the micronuclear envelope highly unstable and rupture-prone. Follo... see more

Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress. Mature ca... see more

The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins. A common feature of these diseases, named laminopathies, is... see more

The nuclear envelope (NE) of eukaryotic cells provides a physical barrier for messenger RNA (mRNA) and the associated proteins (mRNPs) traveling from sites of transcription in the nucleus to locations of translation processing in the cytoplasm. Nuclear po... see more

The mammalian nuclear lamina proteins—prelamin A- and B-type lamins—are post-translationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxy-terminal CAAX (C, cysteine; a, aliphatic amino acid; X, any amino acid... see more

Mutations in genes encoding nuclear envelope proteins, particularly LMNA encoding the A-type lamins, cause a broad range of diverse diseases, referred to as laminopathies. The astonishing variety of diseased phenotypes suggests that different mechanisms c... see more

The present review summarizes recent cytochemical findings on the functional organization of the nuclear domains, with a particular emphasis on the relation between nuclear envelope- associated proteins and chromatin. Mutations in two nuclear envelope-ass... see more

Hurricanes pose major threats to coastal communities and sensitive infrastructure, including nuclear power plants, located in the vicinity of hurricane-prone coastal regions. This study focuses on evaluating the storm surge and wave impact of low-probabil... see more

Hutchinson–Gilford progeria syndrome (HGPS), also known as juvenile progeria, is a genetic disorder associated with abnormalities in the structure and function of nuclear envelope proteins. The disease begins in childhood and causes rapid aging. Affected ... see more

1 of 483 pages  |  10  records  |  more records»