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15.927  Articles
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A protein complex consists of two or more proteins that are linked together through protein–protein interactions. The proteins show stable/transient and direct/indirect interactions within the protein complex or between the protein complexes. Protein comp... see more

Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK... see more

Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large amounts within cancer microenvironments that will ultimately promote neoplastic progression, notably by suppressing the host’s T-cell immunosurveillance. This e... see more

Background: Cancer is a term that is used to describe a wide range of diseases, but they all have some characteristics in common. The goal of this review is to highlight the most commonly used cancer models as well as their role in tumor biology. Although... see more

This review focuses on neoadjuvant chemotherapy for breast cancer which introduces practical issues for pathologists, including predicting response, optimising specimen handling, size measurement and assessment of residual disease, and recent advances in ... see more

AbstractThe discovery of microRNA, a small non coding RNA, has shed light to the dark matters (98%) of the genome. This finding resulted in a Nobel Prize awarded to Fire and Mello in 2006. miRNA a small non coding RNA  which played  a ... see more

Lung cancer is a tumor pathology that includes a group of neoplasms with different biological characteristics, which determine the course of the disease and the potential treatment response depending on the subtype diagnosed. Non-small lung carcinoma corr... see more

Upper aerodigestive tract cancers (i.e., oral cavity, pharynx, larynx, esophagus, and lungs) are one of the most prevalent and leading causes of cancer-related deaths. Drug resistance is a big challenge for successfully treating these cancers. Recent stud... see more

Bladder cancer (BC) is the 9th most commonly diagnosed cancer worldwide, with the highest rates in developed countries. About ¾ of thepatients are men. The risk of developing of malignancies increases with chronic inflammation. Chronic inflammation can be... see more

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