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18.623  Articles
1 of 1.863 pages  |  10  records  |  more records»
Carvedilol (CVD) is a non-selective ß-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD. In silico study using the ligand-ligand doc... see more

BackgroundA solid dispersion formulation (SD) involves dispersion of poor water soluble active pharmaceutical ingredients (API) in a solubility enhancing polymer with the uttermost goal of improving the oral bioavailability of the API.ObjectiveThis study ... see more

Investigation on in vitro and in vivo behavior of solid dispersions containing Tolvaptan is the focus of the present research work. The effect of various hydrophilic polymers on the aqueous solubility was studied. Kleptose HPB was selected as carrier... see more

The basic objectives of this study were to prepare and characterize solid dispersions of poorly water-soluble drug fluconazole using hydrophilic carriers by spray drying technique. In the present study, a spray drying technique has been used to prepare so... see more

Several technical factors related to penicillin G intramuscular injection can affect its bioavailability and hence reduce the efficacy of rheumatic fever prevention program. When small amount of diluent is used, the powder is not completely dissolved and ... see more

Solid dispersions (SD) of gliclazide (Gli); a poorly water soluble drug and Vitamin E TPGS (Vit E),  Gelucire 44/14 (Gel44) and Gelucire 50/13 (Gel50) prepared by fusion method. Prepared solid dispersions were subjected for solubility studies in vari... see more

Oxcarbazepine has low solubility and low oral bioavailability, so it’s a challenge to formulate suitable dosage form. In this present investigation, to improve the dissolution rate and solubility, skimmed milk is used as a carrier. Physical mixers were pr... see more

In the present study, immediate release solid dispersion of Repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-facto... see more

The objective of the present investigation is focused on the preparation of solid dispersions containing Nevirapine. The effect of various hydrophilic polymers on the aqueous solubility was studied. Kolliphor P188 was selected as carrier and solid dispers... see more

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