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48  Articles
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Background: Breast cancer is the most common malignancy in women. In the countries of Central and Eastern Europe founder mutations in the BRCA1 and BRCA2 genes are responsible for a significant proportion of breast cancer cases; however, regional differen... see more

Este estudo teve como objetivo analisar variantes encontradas nos genes BRCA1 e BRCA2 com intuito de comparar as diferentes predições in silico de ferramentas distintas, além de investigar variantes candidatas à desequilíbrio de ligação (LD). Para as anál... see more

Women who carry a pathogenic mutation in the breast cancer susceptibility genes BRCA1 or BRCA2 (BRCA) have markedly increased risks of developing breast and ovarian cancers during their lifetime. It has been estimated that their breast and ovarian cancer ... see more

AbstractIn this time of amounting cancer incidence and mortality, genetic testing may be greatly valuable in deciding on appropriate clinical management. It is unfortunate that the test is not a practical interrogative problem. When positive, the patients... see more

Objective: Breast cancer constitutes 29 % of estimated new cases of cancer in women, and it is also one of the major cause of death in all cancer types. In this study, DNA samples of familial breast cancer patients with BRCA1 and BRCA2 mutations which had... see more

Multiple primary tumors are understudied cancer. Criteria multiplicity of primary tumor: a tumor should be located in different organs, their morphology must be unequal, and each tumorshould provide their own metastases. At the time of appearance there ar... see more

The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract t... see more

Repairing damage and errors that occur in the DNA molecule is essential to maintain the integrity of the genome and cell viability. Deficits in DNA repair mechanisms lead to an increased risk of genetic instability and contribute to neoplastic transformat... see more

Resumo: a descoberta dos genes BRCA1 e BRCA2 avançou na avaliação de risco das famílias afetadas pelo câncer de mama, mas a identificação dos marcadores moleculares associados com o risco aumentado para a neoplasia em pacientes sem antecedentes familiares... see more

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