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66  Articles
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A growing number of human pathogens are becoming resistant to most common antibiotics.  Each year, antibiotic-resistant infections are responsible for 35,000 deaths in the United States and billions of dollars in health care costs. The development of... see more

The CDC classifies Francisella tularensis as a Category A bioterrorism agent. Due to the growing global threat of antibiotic resistant bacteria, novel therapeutics against F. tularensis must be developed.  Resazomycins are resazurin (Rz)-based compou... see more

Francisella tularensis, the causative agent of tularemia, is a pathogenic gram-negative bacterium that enters human red blood cells (RBCs). Previous investigations suggest that invasion of RBCs helps F. tularensis survive in the gut of arthropods – a tran... see more

The mouse monoclonal and polyclonal antibodies were produced for the detection of intracellular pathogenand potential warfare agent Francisella tularensis. Antibody titers obtained were 1:640 for polyclonal antibodiesand 1:320 for monoclonal antibodies. B... see more

Francisella tularensis is a highly virulent Gram-negative bacterium, which infects numerous cell types of its mammalian host causing the disease tularemia. In addition to invading phagocytes of the human immune system as well as other non-phagocytic cells... see more

Francisella tularensis is an intracellular pathogen and the causative agent of tularemia. The F. tularensis type six secretion system (T6SS) is required for a number of host-pathogen interactions including phagolysosomal escape and invasion of erythr... see more

GAGE PYLES and JOSEPH HORZEMPA, Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV. Utilizing the Francisella tularensis Live Vaccine Strain as a novel vaccine platform against the Ebola Virus.Francisella tularensis ... see more

Francisella tularensis is a zoonotic bacterial pathogen that causes severe disease in a wide range of host animals, including humans. Well-developed murine models of F. tularensis pathogenesis are available, but they do not meet the needs of all investiga... see more

Francisella tularensis, a Gram-negative coccobacillus, is a highly virulent pathogen responsible for several zoonotic outbreaks in Europe in the last few decades. The authors report the case of a 46-year-old male who developed fever, myalgias and headache... see more

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