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21  Articles
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The genus Megalocytivirus in the family of Iridoviridae encompasses isolate of red sea bream iridovirus (RSIV). In the present study, grunt fin (GF) cells were treated with red sea bream iridovirus (RSIV) in combinations with interferons (IFNs) ... see more

Background: A mixture of five herbal extracts called internatural (INT), which is prepared from pumpkin seeds, purple turmeric, pearl barley, corn pistil, and cinnamon, is widely used by people in Japan and elsewhere for its immunity-enhancing effect... see more

Aproximación a la dinámica de la respuesta inmune en la infección por la COVID-19 / Approach to the dynamics of the immune response in the COVID-19 infection Aproximación a la dinámica de la respuesta inmune en la infección por la COVID-19 / Approach to the dynamics of the immune response in the COVID-19 infectionObjetivo: caracterizar las particularidades de la dinámica de larespuesta inmune durante la infección por la COVID-19.Desarrollo: el sistema inmune juega un papel en la patogeniade la COVID-19 en el que el infiltrado de neutrófilos es un eventoimportante durante la enfermedad. La producción de citocinasproinflamatorias por activaciones anómalas de las vías deseñalización y desregulación en los interferones, son mecanismosinvolucrados en la respuesta inmune de esta enfermedad. Estasevidencias justifican el uso de tratamientos inmunosupresorescomo la metilprednisolona en los pacientes con cuadros graves. Larespuesta inmune adaptativa aparece después de las dos semanasde infección, aunque la IgM se detecta desde la primera semana.La respuesta de los linfocitos T es indispensable en la completaeliminación de la infección viral.Conclusiones: el sistema inmune juega un papel importanteen la destrucción del epitelio alveolar y el desarrollo de lossíntomas graves de la COVID-19, de ahí que los tratamientosinmunomoduladores pueden beneficiar a estos pacientes.Palabras clave: COVID-19; coronavirus; respuesta inmune;inmunopatogenia.ABSTRACTObjetivo: to characterize the peculiarities of the dynamics of theimmune response during infection with COVID-19.Development: the immune system plays a role in the pathogenesisof COVID-19, where the neutrophil infiltrate is an important eventduring the disease. The production of proinflammatory cytokinesby abnormal activations of the signaling and dysregulationpathways in interferons are mechanisms involved in the immuneresponse of this disease. These evidences justify the use of immunosuppressive treatments such as methylprednisolone inpatients with severe symptoms. The adaptive immune responseappears after two weeks of infection, although IgM is detectedfrom the first week. The response of T lymphocytes is essential inthe complete elimination of the viral infection.Conclusions: the immune system plays an important role inthe destruction of the alveolar epithelium and the developmentof severe symptoms of COVID-19, hence immunomodulatorytreatments can benefit these patients.Keywords: COVID-19; coronavirus; immune response;immunopathogenesis.

respuesta inmune durante la infección por la COVID-19.Desarrollo: el sistema inmune juega un papel en la patogeniade la COVID-19 en el que el infiltrado de neutrófilos es un eventoimportante durante la enfermedad. La producción de citocinasproinflamatoria... see more

Interferon alpha is a molecule associated with stimulation of immune system cells, resulting in an anti-proliferative and immunomodulatory effect. It has been demonstrated that interferon reduces the number of platelets, leukocytes, and erythrocytes in pa... see more

Kaposi’s sarcoma-associated herpesvirus or Human herpesvirus-8 (KSHV/HHV-8), an oncogenic human herpesvirus and the leading cause of cancer in HIV-infected individuals, is a major public health concern with recurring reports of epidemics on a global level... see more

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, includi... see more

Introduction: Patient registries allow better evaluations of therapeutic outcomes and support personalized health care in several conditions. This study aimed to implement a local registry in a multiple sclerosis center in Portugal, in order to carry out ... see more

Pathogenic escherichia in young children remains one of the main factors of bacterial lesions of the gastrointestinal tract. Aim. To study the effectiveness of the use of interferons in the treatment of escherichiosis in children infected with Epstein-Bar... see more

The study is aimed at identifying the key aspects of the national pharmacopeial regulation of the circulation of biotechnological medicines in the Russian pharmaceutical market and at studying the range of major groups based on the analysis of restrictive... see more

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