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18.797  Articles
1 of 1.881 pages  |  10  records  |  more records»
This paper presents the results of predicting drug-likeness, biological activity, and toxicity for 8 new derivatives of 3,5-bis(hydroxymethyl)tetrahydro-4H-pyran-4-one using bioinformatic methods. The physicochemical and pharmacokinetic parameters of the ... see more

The article is devoted to the development of a printed ultra-wideband miniature antenna that can be used for microwave radiometry. An antenna design with a ring-shaped radiator has been proposed, which provides reception of microwave radiation from biolog... see more

Topicality. Amlodipine besylate belongs to the group of calcium channel blockers, derivative from 1,4-dihydropyridine. The pharmacological effects of amlodipine are the cause its effectiveness in the treatment of hypertension and the vasospastic form of s... see more

Electromagnetic pollution of the environment has become a significant environmental factor. The intensity of technogenic electromagnetic fields far exceeds the background indicators to which organisms have adapted in the course of evolution, in particular... see more

Topicality. Amlodipine besylate belongs to the group of calcium channel blockers, derivative from 1,4-dihydropyridine. The pharmacological effects of amlodipine are the cause its effectiveness in the treatment of hypertension and the vasospastic form of s... see more

The conservation of genetic information through the ages can not be explained unless one assumes the existence of genomic error-correcting codes, our main hypothesis. Shielding by phenotypic membranes does not protect the genomes against radiations and th... see more

Diffusion channels are involved in the selective uptake of nutrients and form the largest outer membrane protein (OMP) family in Gram-negative bacteria. Differences in pore size and amino acid composition contribute to the specificity. Structure-based mul... see more

Living systems display a variety of situations in which non-equilibrium fluctuations couple to certain protein functions yielding astonishing results. Here we study the bacterial channel OmpF under conditions similar to those met in vivo, where acidic res... see more

Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5. We review evidence for the formation of different TRPC1... see more

1 of 1.881 pages  |  10  records  |  more records»