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14  Articles
1 of 2 pages  |  10  records  |  more records»
One of the most frequent and formidable consequences of traumatic brain injury (TBI) is post-traumatic epilepsy (PTE), which is the main identified cause of symptomatic epilepsy at a young age.The work highlights the "trigger" mechanisms of brain damage, ... see more

This article provides an overview of neuroimaging biomarkers in experimental epileptogenesis and refractory epilepsy. Neuroimaging represents a gold standard and clinically translatable technique to identify neuropathological changes in epileptogenesis an... see more

Background. Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS) and affects 1% of human population. A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic... see more

As described initially from clinical and experimental studies, P-glycoprotein (P-gp) plays a central role in the pharmacoresistance of epilepsy, acting by efflux of AEDs mainly at blood brain barrier (BBB) level. However, repetitive seizures can produce b... see more

Microglia are the resident immune cells in the brain that constitute the brain’s innate immune system. Recent studies have revealed various functions of microglia in the development and maintenance of the central nervous system (CNS) in both health and di... see more

Background. The identification of a valid experimental model of absence epilepsy is important for the investigations of its mechanisms and for the evaluation and justification of new experimental treatment options. The genetic rat models such as rats of t... see more

The results of investigation of the antiepileptic activity of promising herbal anticonvulsants – Fumaria schleicheri (FSDE) and Ocimum basilicum (OBDE) dry extracts – are presented. The herbal remedies were administered intragastrically in the conditional... see more

Based on current literature analysis this review provides information on various issues of a woman’s reproductive system functioning under altered conditions of a pathologically functioning brain during epilepsy, outlines possible pathogenetic mechanisms ... see more

Background. The identification of a valid experimental model of absence epilepsy is important for the investigations of its mechanisms and for the evaluation and justification of new experimental treatment options. The genetic rat models such as rats of t... see more

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