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21  Articles
1 of 3 pages  |  10  records  |  more records»
UGT1A1 la` enzyme liên quan dê´n ta´c du?ng phu? gi?m b?ch c?u trung tính và tiêu ch?y khi su? du?ng irinotecan trong diê`u tri? bê?nh nhân ung thu. Mô?t sô´ biê´n thê? cu?a UGT1A1 gây nên ca´c ta´c du?ng phu? d? nghiêm tr?ng dâ~n dê´n câ`n gi?m li?u ho?c... see more

We have recently demonstrated that the oral bioavailability of irinotecan (80 mg/kg) can be increased at least 7-fold by co-administration of the P-gp blocker verapamil (25 mg/kg, Oral). As a result, co-treatment with P-gp inhibitor could be a useful stra... see more

The creation of the liposomal irinotecan is one of the main ways to reduce toxicity and increase the effectiveness of chemotherapy. Lyophilization makes it possible to obtain a product with a guaranteed stability of the size and encapsulation efficiency.A... see more

Were obtained liposomes with irinotecan by “pH gradient” method. To determine the internal volume of liposomes used control method of citrate ion in ultrafiltrate by the HPLC. It was determined that the internal volume of liposomes obtainedis 10.15 % of t... see more

At present, there is an increasing interest in developing new ways of drug delivery and targeted therapy, using nanotechnology and nanomaterials.Aim – to study the order of carrying out of pharmaceutical development of liposoms with cytostatics. Propose t... see more

The creation of the liposomal irinotecan is one of the main ways to reduce toxicity and increase the effectiveness of chemotherapy. Lyophilization makes it possible to obtain a product with a guaranteed stability of the size and encapsulation efficiency.A... see more

Were obtained liposomes with irinotecan by “pH gradient” method. To determine the internal volume of liposomes used control method of citrate ion in ultrafiltrate by the HPLC. It was determined that the internal volume of liposomes obtainedis 10.15 % of t... see more

At present, there is an increasing interest in developing new ways of drug delivery and targeted therapy, using nanotechnology and nanomaterials.Aim – to study the order of carrying out of pharmaceutical development of liposoms with cytostatics. Propose t... see more

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