Journal title
EUREKA: Health Sciences

   
ARTICLE
TITLE

The method of random balance for studying the influence of excipients quantities on technological parameters of tablets based on Origanum vulgare L. dry extract

SUMMARY

The aim. The aim of the research was to study the influence of excipients amount on the technological parameters of the compression mixture and tablets based on dry extract of Origanum vulgare L. herb using the method of random balance.Materials and methods. Objects of the study – Origanum vulgare L. herb dry extract, 8 excipients that have been studied at two quantitative levels. The tablets were prepared by direct compression method. The formulations were designed according to the method of random balance. The technological parameters of the compression mixture and tablets based on Origanum vulgare L. herb dry extract have been studied as a function of quantitative factors: silicon, magnesium carbonate basic, dioxide magnesium aluminometasilicate (Neusilin S1®), isomalt (GalenIQ™720), F-melt® Type C (co-spray dried excipients), sucralose, berry flavor and citric acid.Results and discussion. The increase in the amount of Neusilin S1®, GalenIQ™720 and F-melt®, and the decrease in the amount of magnesium carbonate basic and silicon dioxide improved the flowability expressed by the Hausner ratio. Results of bulk density and tapped density of the compression mixture depended on the quantities of GalenIQ™720 and F-melt®. All formulations of the prepared tablets had the rapid disintegration and ranging from 6 to 15 minutes. Resistance for crushing and friability tablets’ were improved with a decrease in the amount of silicon dioxide and increase in the amount of Neusilin S1®, F-melt® and sucralose. Higher resistance to moisture of tablets based on Origanum vulgare L. dry extract was obtained by using Neusilin S1®, F-melt® and sucralose on the upper levels.Conclusions. The tablets based on Origanum vulgare L. herb dry extract were successfully manufactured by direct compression method. The random balance method enabled us to identify the most significant quantitative factors to optimize their composition in the tablets based on the dry extract of Origanum vulgare L. herb.

PAGES
pp. 73 - 81

 Articles related

I. P. Atamanyuk, V. Y. Kondratenko, A. S. Kramarenko, O. E. Novikov, V. Y. Lykhach    

Improvement of sow reproductive performance is a key factor determining the efficiency of the pig production cycle and profitability of pork production. This article presents the solution of an important scientific and practical problem of individual for... see more


Factores relacionados con el bajo peso al nacer en el municipio La Lisa, en el período 2010-2014 Factores relacionados con el bajo peso al nacer en el municipio La Lisa, en el período 2010-2014Introducción: el bajo peso al nacer es en la actualidad una de las causas de morbimortalidad perinatal y uno de los indicadores para evaluar los resultados de la atención prenatal. Objetivo: determinar los principales factores de riesgos del bajo peso al nacer en recién nacidos del municipio La Lisa. Material y Métodos: se realizó un estudio de casos y controles en el Municipio La Lisa en el período de 2010 a 2014, de las pacientes atendidas en el Hospital Docente "Eusebio Hernández". El universo estuvo constituido por un total de 364 neonatos bajo peso, la muestra del grupo estudio se correspondió con 257 recién nacidos bajo peso y el grupo control fue una muestra aleatoria de 261 casos con un peso igual o superior a 2 500 gr; se excluyó del estudio a aquellas gestantes cuyo parto no se produjo en este hospital y las que aportaron embarazos gemelares; se obtuvo la información por medio de las historias clínicas del Hospital. Se analizaron los datos y se determinó el Riesgo Relativo. Resultados: Los factores de riesgo más frecuentes fueron: la presencia de 2 ó 3 abortos previos al embarazo, las enfermedades asociadas al embarazo como son la Anemia, Sepsis Urinaria y Vaginal; se demostró la asociación significativa de la aparición del recién nacido bajo peso y los trastornos hipertensivos. Conclusiones: los recién nacidos bajo peso siguen mostrando un incremento en el área de salud, e  inciden como factores de riesgo frecuente: la anemia, la sepsis tanto vaginal como urinaria y la hipertensión arterial.Palabras clave: recién nacidos, bajo peso al nacer, factores de riesgo, trastornos hipertensivos, embarazo.ABSTRACTIntroduction: low birth weight (LBW) has been considered as one of the most important cause of perinatal morbidity and mortality doing one of the indicator used to assess the results of prenatal health attention quality. Objective: Identify the main risk factors of low birth weight and whether there was an association between the occurrence of low birth weight and Arterial Hypertension in the Municipality. Material y Methods: a study of cases and controls was performed in the municipality La Lisa in the period from 2010 to 2014 in order to identify the main risk factors of low birth weight and whether there was an association between the occurrence of low birth weight and Arterial Hypertension in pregnant women living in the municipality who were treated at the Maternal University Hospital Eusebio Hernandez.  The universe consisted of a total of 423 infants underweight, the study group sample corresponded to 257 LBW and the control group was a simple random sample of 261 cases with a weight equal to or greater than 2500 gr. obtained from the same area of health, the study excluded those pregnant women whose delivery did not occur in the previous Hospital and who contributed twin pregnancies, the information was obtained through medical records from the Hospital. Data determined for each of the Relative Risk factors were analyzed. Results: Risk factors that affected were: the presence of 2 or 3 pre-pregnancy abortions, pregnancy-associated diseases such as anemia, urinary Sepsis, Sepsis Vaginal, the significant association of the appearance of the underweight newborn were also demonstrated and also the hypertensive disorders of pregnancy. Conclusions: the municipality to maintain the increase of low birth weight, risk factors that affected were: the anemia, the presence of 2 or 3 pre-pregnancy abortions, urinary and vaginal sepsis, and also hypertensive disorders of pregnancy.Key words: low birth weight, newborn, risk factors, hypertension disorders, pregnancy.

Regla Padrón Beltrán,Roberto Antonio Garcés Rodríguez    

Objetivo: determinar los principales factores de riesgos del bajo peso al nacer en recién nacidos del municipio La Lisa. Material y Métodos: se realizó un estudio de casos y controles en el Municipio La Lisa en el período de 2010 a 2014, de las paciente... see more


Miloš Ilic,Ružica Igic,Mirjana Cuk,Dragana Vukov    

Paper description:Despite the importance of bryophytes in forests, these plants are usually ignored in forest ecosystem studies, and a standardized methodology for quantifying bryophyte abundance in forest communities is still lacking. Among several used... see more


Wei Zhao, Yi Fu, Xiaosong Wei and Hai Wang    

This paper proposed an improved image semantic segmentation method based on superpixels and conditional random fields (CRFs). The proposed method can take full advantage of the superpixel edge information and the constraint relationship among different p... see more

Revista: Applied Sciences

Maloth Swathi, Ratnam Andallu, Manekar Balasaraswathi, Vederay Suvarna    

The aim: To study the efficacy and safety of combined mifepristone and misoprostol used in second-trimester abortion(= 12 and = 20 weeks) in comparison with only vaginal misoprostol.Materials and methods: This study was a prospective comparative randomis... see more