SUMMARY
Vastyanov R. S., Stoyanov A. N., Demidov V. M., Bylsky D. V., Antonenko S. A., Nescoromnaya N. V.,Sivolap M. Yu., Pulyk ?. R. ??????????? ??????????????? ? ?????????????? ??????: ???????? ???????????????? ?????????? = Traumatic and hypoxic damages: common pathogenetic mechanisms. Journal of Education, Health and Sport. 2016;6(9):285-304. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.61768http://ojs.ukw.edu.pl/index.php/johs/article/view/3845 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.08.2016. Revised 25.08.2016. Accepted: 06.09.2016. ??? 616-092;616-001;616.831-005.4+557.146.1 ??????????? ??????????????? ? ?????????????? ??????: ???????? ???????????????? ?????????? ?. ?. ?????????, ?. ?. ???????, ?. ?. ???????, ?. ?. ????????, ?. ?. ?????????, ?. ?. ???????????, ?. ?. ???????, * ?. ?. ????? ???????? ???????????? ??????????? ???????????, ?????? * ??????????? ???????????? ???????????, ??????? ????????????????? ? ????????????? ??????? ??????????? ????????? ???????????????? ? ??????????????? ?????? ? ????? ???????? ? ???????-???????? ??????? (???), ??????????? ????????? (??) ? ?????? ???????????? (??). ????????????? ???? ??????????? ???????????? ??????? ??????? ???????-?????, ????????????-1 ? -6 ? ?????????? ??????? ??????? ?????? ????? ? ???????? ?????????????? ??????? ??????????????? ? ?????????????? ??????????? (???). ???????? ??????? ?????????? ? ????? ???????? ? ??? ????????????? ????????? ??? – ??? ? ?? - ? ???????? ?????????? ??????????????? ????????? – ????????, ??? ? ??, - ??? ?????????? ? ??????? 14 ???? ??????????. ?????????? ?????? ??????????????? ?? ???????? ??????? ????????????????? ????????? ? ?? ????????? ???????????????? ??????? ? ????????? ????????. ?????????? ???????????? ? ??????????? ??????? ???????????? ???????????? ???????????? ??? ? ??, ? ????? ?????????? ????????, ??? ? ?? ?? 7 ???? ????? ?????????????????? ??????????????? ?? ? ?? 14 ???? ????? ????????????? ??? ? ??. ?????????? ?????? ??????????????? ? ???????????? ?????????????? ????????????? ??????? ? ???????? ?????? ??? ? ??????? ??????????????????? ????????? ???. ?????????? ???????????? ? ????????? ???????? ??????? ???????? ???????, ??? ???????? ????????????????? ??????????????? ???????????????? ???????????? ???????????? ????????? ? ????????? ? ??????????????? ? ?????????????? ????????????? ???????.???????? ?????:?????????????? ? ????????????? ???????????, ???????????, ???????????????? ?????????, ?????????????? ????????????? TRAUMATIC AND HYPOXIC DAMAGES: COMMON PATHOGENETIC MECHANISMS R. S. Vastyanov, A. N. Stoyanov, V. M. Demidov, D. V. Bylsky, S. A. Antonenko, N. V. Nescoromnaya, M. Yu.Sivolap, * ?. R. Pulyk Odessa National Medical University, Odessa; *UzhgorodNationalUniversity, Uzhgorod, SummaryLipid peroxidation and antiradical defense comparative peculiarities were studied in plasma of animals with brain trauma (BT), ischemic stroke (IS) and acute pancreatitis (AP). Tumor necrosis factor-alpha, interleukins-1 and -6 levels and nitric oxide synthesis enzyme activity were evaluated in the conditions of the traumatic and hypoxic damages (THD) models. Intermediate products of peroxidation – MDA and DK – levels accumulation as well as antioxidant enzymes – catalase, SOD and GP – activity decreasing in blood plasma of THD animals were evident throughout 14 days. The data obtained are in favour of proinflammatory cytokines synthesis enhancement and nitratergic system activation under the model conditions. Ronkoleukin administration in majority cases results in MDA and DK levels normalization together with catalase, SOD and GP activity increasing on the 7th day of the experimental trials in case of experimental AP and on the 14th day after BT and IS modelling. The results indicate both the nervous and immune systems pathological disintegration as a common leading THD pathophysiological mechanism.Ronkoleukin administration in these model conditions revealed protective effects that serve as an experimental background of its clinical testing reasonability in patients with inner organs traumatic and hypoxic damages.Keywords: traumatic and hypoxic damage, ronkoleukin, pathogenetic mechanisms, pathological desintegration, ?????????????? ????????????? ? ???????????? ??????: ?????????? ?????????????? ??????????. ??????? ???? ? ????????????? ??????? ??????????? ???????? ???????????????? ? ???????????????? ??????? ? ????? ?????? ? ???????-???????? ??????? (???), ????????? ????????? (??) ? ??????? ???????????? (??). ????????? ???? ?????????? ???????????? ??????? ??????? ???????-?????, ????????????-1 ? -6 ?? ?????????? ??????? ??????? ?????? ????? ? ?????? ???????????? ??????? ????????????? ? ???????????? ???????? (???). ???????? ?????? ??????????? ? ????? ?????? ? ??? ????????? ????????? ??? - ??? ? ?? - ? ???????? ?????????? ??????????????? ????????? - ????????, ??? ? ??, - ?? ???????????? ???????? 14 ??? ???????. ???????? ???? ???????? ??? ????????? ??????? ???????????? ????????? ? ??? ????????? ?????????????? ??????? ? ????????? ??????. ???????????? ???????????? ? ????????? ???????? ?????? ???????????? ???????????? ??? ? ??, ? ????? ?????????? ????????, ??? ? ?? ?? 7 ???? ????? ?????????????????? ??????????? ?? ? ?? 14 ???? ????? ??????????? ??? ?? ??. ?????????? ?????? ???????? ??? ?????????? ???????????? ????????????? ???????? ?? ??????? ?????? ?? ??? ???????? ??????????????????? ????????? ???. ???????????? ???????????? ? ????????? ?????? ??????? ??????? ??????, ?? ? ????????????????? ??????? ??????????? ?????????? ?????????? ????????? ? ????????? ? ????????????? ? ???????????? ?????????? ???????.??????? ?????: ??????????? ?? ?????????? ????????, ???????????, ????????????? ?????????, ??????????? ?????????????