Home  /  Cancers  /  Vol: 11 Núm: 1 Par: January (2019)  /  Article
ARTICLE
TITLE

Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?

SUMMARY

Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological ROS inducers, therefore, has been widely investigated as an approach to enhance aerobic radiosensitization. However, this strategy was overlooked in hypoxic counterpart, one of the most important causes of radiotherapy failure, due to the notion that hypoxic cells are immune to ROS insults because of the shortage of ROS substrate oxygen. Paradoxically, evidence reveals that ROS are produced more in hypoxic than normoxic cells and serve as signaling molecules that render cells adaptive to hypoxia. As a result, hypoxic tumor cells heavily rely on antioxidant systems to sustain the ROS homeostasis. Thereby, they become sensitive to insults that impair the ROS detoxification network, which has been verified in diverse models with or without radiation. Of note, hypoxic radioresistance has been overviewed in different contexts. To the best of our knowledge, this review is the first to systemically summarize the interplay among radiation, hypoxia, and ROS, and to discuss whether perturbation of ROS homeostasis could provide a new avenue to tackle hypoxic radioresistance.

 Articles related

Christophe Deben, Vanessa Deschoolmeester, Jorrit De Waele, Julie Jacobs, Jolien Van den Bossche, An Wouters, Marc Peeters, Christian Rolfo, Evelien Smits, Filip Lardon and Patrick Pauwels    

The compound APR-246 (PRIMA-1MET) is a known reactivator of (mutant) p53 and inducer of oxidative stress which can sensitize cancer cells to platinum-based chemotherapeutics. However, the effect of a hypoxic tumor environment has been largely overlooked ... see more

Revista: Cancers

Adam B. Edwards, Ryan S. Anderton, Neville W. Knuckey and Bruno P. Meloni    

Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality and morbidity in neonates, with survivors suffering significant neurological sequelae including cerebral palsy, epilepsy, intellectual disability and autism spectrum disord... see more

Revista: Brain Sciences

Uni Gamayani,Popon Gartika,Luh Putu Meidha,Aih Cahyani,Siti Aminah Siti Aminah,Ramdan Panigoro    

Beta-thalassaemia major (b-th) is a chronic genetically haematological disorder due to defects in the synthesis of globin chains of haemoglobins [1]. Indonesia is among a group of countries with high prevalence of thalassaemia [2]. The most common treatm... see more


Abha Maskey,Sharon Molnar,Gerald Hankins    

Modern medicine has been focusing on proving new and alternative chemotherapeutic compounds with high tumor cytotoxicity and reduced side effects to combat drug resistance and improve drug efficacy in cancer treatment. Organometallic compounds have uniqu... see more


R. Yanko, V. Berezovskii, E. Chaka, M. Levashov, L. Plotnikova, I. Litovka    

There are only few studies in which the effect of intermittent normobaric hypoxia on the liver status in animals and people with arterial hypertension has been investigated. That’s why it’s necessary to carry out these studies in animals with high blood ... see more