SUMMARY
The aim of the work was to study acute toxicity, the irritating and allergic effects of a new combined cream “Dermalipoin” consisting of a-lipoic acid, urea, olive oil, tea tree oil, PEG-400. It has been found that the LD50 of the cream with intragastric introduction is greater than 5000 mg/kg, and when applied to the skin LD50 > 2810 mg/kg; in accordance with the classification of K.K.Sidorov it allows to refer this cream to the class of almost nontoxic substances (the V-th toxicity class). “Dermalipoin” cream shows no irritative action in contact with the mucous membrane of the eye and sensitizing actions in external application.