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Hideaki Obata    

Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, h... see more


Palmah M. Nyadar,Volodymyr V. Oberemok,Ilya V. Zubarev    

Several genes have been identified to play important roles associated with sex selection in Drosophila melanogaster. An essential part is attributed to the sex-lethal gene that depends on the expression of the X:A (number of chromosomes to autosomes) rat... see more


Fiona H. Tan, Tracy L. Putoczki, Jieqiong Lou, Elizabeth Hinde, Frédéric Hollande, Julie Giraud, Stanley S. Stylli, Lucia Paradiso, Hong-Jian Zhu, Oliver M. Sieber and Rodney B. Luwor    

Signal transducer and activator of transcription 3 (STAT3) signaling is a major driver of colorectal cancer (CRC) growth, however therapeutics, which can effectively target this pathway, have so far remained elusive. Here, we performed an extensive scree... see more

Revista: Cancers

Yu. Shesterenko,I. Romanovska,O. Sevastyanov,A. Karpenko,S. Zanoza    

Melanin pigmentation of skin plays the most important role in the protection of organism against UV-irradiation, but the excessive accumulation of melanin brings to toxic melanodermia, melasma, lentigo and other skin lesions. Tyrosinase is the key enzyme... see more


Etai Adam, Hye Na Kim, Eun Ji Gang, Caitlin Schnair, Solomon Lee, Solah Lee, Sajad Khazal, Osanna Kosoyan, Marina Konopleva, Chintan Parekh, Deepa Bhojwani, Alan S. Wayne, Hisham Abdel-Azim, Nora Heisterkamp and Yong-Mi Kim    

The quest continues for targeted therapies to reduce the morbidity of chemotherapy and to improve the response of resistant leukemia. Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stromal cells triggers intracellular signals that pr... see more

Revista: Cancers