ARTICLE
TITLE

Synthesis and application of (18F) fluorodeoxyglucose in oncology diagnosis

SUMMARY

[18F] Fluorodeoxyglucose ([18F] FDG) is the most commonly used radiopharmaceutical in clinical positron emission tomography (PET) in oncology. Cancer cells create their own specific microenvironment to survive and grow. Specific tumor microenvironment contributes to cancer metabolic reprogramming. Therefore, even with sufficient oxygen availability, cancer cells choose anaerobic glycolysis. Cancer cells compensate less energy efficient process by increasing the intensity of anaerobic glycolysis. Tumor cells have a high rate of metabolism and because of this, they take up more of the radioactive glucose (FDG). This makes the tumor cells appear more visible than other areas on the PET scan pictures.This paper presents nucleophilic synthesis of the [18F] FDG marker and basics of tumor development which can affect the [18F] FDG biochemical significance. Reference was made to clinical images obtained in PET technology using the [18F] FDG radiopharmaceutical.

 Articles related

Elena V. Beloglazova, Svetlana I. Procenko, Lyudmila A. Safonova, Svetlana I. Vasenina    

The article focuses on the issues of ICT-based competence development as a basic component in the system of future teachers professional training. The development of the mentioned competence is stipulated by the global trends in digital economics develop... see more


Alina Shcherbak    

Purpose: Activation of the process of formation of the information society in Ukraine, causes the introduction of information technologies in the practical activities of enterprises, increases the role and importance of information processes as one of th... see more


O. Yarmoschuk, V. Vasylyuk    

The study objective is to analyze some of the modern mobile technologies actively used in the educational process and to identify the criteria and conditions for their effective use.Materials and methods. Within one module, the experimental group (n=23) ... see more


?. ?. ???????, ?. ?. ????????    

Analysis of the literature showed that the problem of introducing automation technologies of information processing and the creation of a database on the physical condition of children and adolescents is important. The purpose of research — to develop an... see more