SUMMARY
Mirlak Izabela, Radajewski Kamil, Ciesielska Natalia, Sokolowski Remigiusz, Podhorecka Marta, Zukow Walery. Osoczowy poziom homocysteiny jako czynnik ryzyka wystapienia zlaman w przebiegu osteoporozy u ludzi w wieku podeszlym = The plasma levels of homocysteine as a risk factor for fractures in osteoporosis in the elderly. Journal of Education, Health and Sport. 2016;6(4):233-239. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50138http://ojs.ukw.edu.pl/index.php/johs/article/view/3465 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016. Osoczowy poziom homocysteiny jako czynnik ryzyka wystapienia zlaman w przebiegu osteoporozy u ludzi w wieku podeszlymThe plasma levels of homocysteine as a risk factor for fractures in osteoporosis in the elderly Izabela Mirlak1, Kamil Radajewski1, Natalia Ciesielska2, Remigiusz Sokolowski3, Marta Podhorecka1, Walery Zukow4 1Sniadecki Specialist Hospital in Nowy Sacz, Poland2Department and Clinic of Geriatrics, Ludwik Rydygier Collegium Medicum in Bydgoszcz NCU, Poland3Department of Hygiene, Epidemiology and Ergonomic, Division of Ergonomics and Exercise Physiologym Ludwik Rydygier Collegium Medicum in Bydgoszcz NCU, Poland4Kazimierz Wielki University, Bydgoszcz, Poland Slowa kluczowe: osteoporoza, homocysteina, menopauza, zlamanie szyjki kosci udowej.Keywords: osteoporosis, homocysteine, menopause, hip fracture. Streszczenie Wstep. Osteoporoza jest choroba charakteryzujaca sie niska masa kostna i zniszczeniami mikroarchitektury tkanki kostnej, która prowadzi do kruchosci kosci i zwieksza ryzyko zlaman. Osteoporoza i zwiazane z nia zlamania kosci maja ogromne znaczenie spoleczne i gospodarcze na calym swiecie. Badania sugeruja, ze maksymalna masa kostna i szybkosc jej utraty zwiazane ze starzeniem, sa zdeterminowane przez czynniki genetyczne w podobnym stopniu jak przez czynniki srodowiskowe. Kumulacja homocysteiny jest toksyczna dla ukladu kostnego (osteoporoza), oka (dyslokacja soczewki) i centralnego ukladu nerwowego (drgawki, zaburzenia psychiatryczne). Wywoluje takze zaburzenia ukladu naczyniowego (udar i inne zdarzenia sercowo naczyniowe).Cel. Wplyw poziomu homocysteiny w osoczu na ryzyko wystapienia osteoporozy i jej powiklan.Materialy i metody. Poslugujac sie slowami kluczowymi przeszukano zagraniczne bazy bibliograficzne: Embase, Medline, ScienceDirect, Web of Science. Przeanalizowano badania kliniczne, opublikowane w jezyku angielskim w miedzynarodowych czasopismach.Wyniki. Zaobserwowano zwiazek pomiedzy stezeniem homocysteiny, a utrata masy kostnej. Poziom homocysteiny w osoczu jest znaczaco wyzszy u kobiet z osteoporoza i odwrotnie proporcjonalny do gestosci kosci kregów ledzwiowych i szyjki kosci udowej.Wnioski. Osoczowy poziom homocysteiny jest czynnikiem ryzyka wystapienia zlaman w przebiegu osteoporozy u ludzi w wieku podeszlym. Abstract Admission. Osteoporosis is a disease characterized by low bone mass and microarchitectural damage of bone tissue which leads to bone fragility and increased risk of fracture. Osteoporosis and related fractures are of great social and economic importance throughout the world. Studies suggest that the maximum bone mass and the rate of loss associated with aging are determined by genetic factors to a similar as by environmental factors. Accumulation of homocysteine is toxic to the bone (osteoporosis), the eye (the dislocation of the lens), and central nervous system disorders (seizures, psychiatric disorders). Also causes vascular disorders (stroke and other cardiovascular events).Objective. Effect of plasma homocysteine level at risk for osteoporosis and its complications. Systematic review.Materials and methods. Using the keywords searched foreign bibliographic databases: Embase, Medline, ScienceDirect, Web of Science. We analyzed clinical trials published in English in international journals.Results. A correlation between homocysteine and bone loss. Homocysteine levels in plasma are significantly higher in women with osteoporosis and inversely proportional to the bone density of lumbar vertebrae and hip.Conclusions. The plasma levels of homocysteine is a risk factor for fractures in osteoporosis in the elderly.