SUMMARY
Gozhenko A. I., Lugovskoy S. P., Samokhina N. A. ??????????? ??????????????????? ???????????? ???????? ????????????????? ???????????????? = The study of morphofunctional features of the development of experimental metallonephropathy. Journal of Education, Health and Sport. 2016;6(4):287-296. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50201http://ojs.ukw.edu.pl/index.php/johs/article/view/3473 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016. ??????????? ??????????????????? ???????????? ???????? ????????????????? ???????????????? ?. ?. ???????, ?. ?. ??????????, ?. ?. ???????? ???????? ???????????? «??????????? ???????-????????? ???????????????? ?????????? ??? ???????», ?. ?????, ??????? ??????????????? ???????????????? ??????????? ???? ????????? ?????? ????? ??????, ?????, ?????? ? ???? 1/50 ??? DL50 ?? ????? ????????, ?? ???????? ???????? ?? ??? ? ????? ?????????? ?????????? ??????, ??? ??????????? ?????????? ??????? ??????????, ???????? ?? ??????? ??????? ? ????????? ?????, ? ????? ??????? ??????? ????? ? ????. ??????????? ??????? ???????? ????? ? ???????? ????????? ??????????? ??????????, ??? ??????????? ??? ??? ???? ????? ????????????? ????????????????: ??? ??? Cd – ???????? ?? 23,6 %, ??? ??? Pb – ?? 22,1 %, ??? ??? Hg – 28,9 %. ???????????? ??????????? ????????? ?????????? ???? ?????, ???? ????????????? ?????????????? ????????? ??? ???????????? ?????? Cd, Hg, Pb, ??? ????????? ? ????????? ??????? ????????? ??????????? ??? ?? ?????? ??????? ??????????? ????????? ???????. ????????? ?????????? ???????? ????????????????? ???????????????? ? ???????? ???????? ????????????? ????????? ?????, ??? ????????? ?????????? ?????????? ????????? ???????, ??????????? ? ??????? ???????? ????????????? ????????? ???????.??????? ?????: ????? ??????, ?????, ????????????????, ?????????, ????????, ?????, ????????? ??????????? ??????????, ???????????? ??????????? ?????, ??????????? ??????, ????????????. THE STUDY OF MORPHOFUNCTIONAL FEATURES OF THE DEVELOPMENT OF EXPERIMENTAL METALLONEPHROPATHY A. I. Gozhenko, S. P. Lugovskoy, N. A. Samokhina Ukrainian Scientific and Research Institute of Transport Medicine, Odessa SummaryEexperimental studies of prolonged exposure of cadmium salts, mercury, lead in the dose of from 1/50 DL50 on the kidney have shown that an important aspect of their actions is the change of indicators of nitrogen metabolism, which was manifested by increased creatinine, urea and uric acid in serum and high urine protein excretion. A characteristic feature of renal disease is the decline in glomerular filtration rate, which was defined when all three of the studied nephrotoxicants: under the Cd decrease by 23,6 %, under the action of Pb - 22,1 %, under the action of Hg – 28,9 %. Morphological studies revealed new facts concerning the morphological characteristics of toxic action of inorganic compounds of Cd, Hg, Pb, which lies in the ability of metals to cause cytopathic effect on individual cells of the structural elements of the nephron. The main mechanism for the development of experimental metallonephropathy is the damage to the epithelium of the proximal tubules of the kidneys, due to a selective disturbance of cellular membranes, mitochondria and lysosomes in the epithelium of the proximal tubules of the nephron.Key words: heavy metals, kidneys, metallonephropathy, creatinine, urea, protein, glomerular filtration rate, and histological examination of the kidneys, tubular apparatus, the epithelial cells. ???????????? ??????????????????? ???????????? ???????? ????????????????? ????????????????? ?. ?. ???????, ?. ?. ?????????, ?. ?. ???????? ?????????? ??? ???????? ??????????, ?.?????? ????????????????? ????????????????? ???????????? ??????????? ??????????? ????? ??????, ?????, ?????? ? ???? 1/50 DL50 ?? ????? ????????, ??? ?????? ???????? ?? ???????? ???????? ????????? ??????????? ?????????? ??????, ??????? ??????????? ?????????? ??????????? ??????????, ???????? ? ??????? ??????? ? ????????? ?????, ? ????? ??????? ??????????? ????? ? ????. ??????????? ????????? ????????? ????? ???????? ???????? ???????? ??????????? ??????????, ??????? ???????????? ??? ???????? ???? ???? ??????????? ????????????????: ??? ???????? Cd – ???????? ?? 23,6 %, ??? ???????? Pb – ?? 22,1 %, ??? ???????? Hg – 28,9 %. ??????????????? ???????????? ????????? ?????????? ????? ?????, ???????????? ??????????????? ?????????????? ???????????? ???????? ?????????????? ?????????? Cd, Hg, Pb, ??????? ??????????? ? ??????????? ???????? ???????? ?????????????? ???????? ?? ????????? ?????? ??????????? ????????? ???????. ??????? ?????????? ???????? ????????????????? ???????????????? ???????? ????????? ???????? ????????????? ????????? ?????, ??????? ??????????? ?????????? ?????????? ????????? ???????, ??????????? ? ??????? ???????? ????????????? ????????? ???????.???????? ?????: ??????? ???????, ?????, ?????????????????, ?????????, ????????, ?????, ???????? ??????????? ??????????, ??????????????? ???????????? ?????, ??????????? ???????, ????????????.