ARTICLE
TITLE

Immune response regulatory disorders and redox homeostasis in pregnant women with isoimmune conflict

SUMMARY

The immunological and biochemical changes caused by pregnancy may uncover new aspects of immune tolerance, applicable in physiological and pathological contexts, and show up new therapeutic strategies for improving pregnancy outcomes. Isoimmune conflict in pregnancy is primarily related to the risk of pre-natal fetal death caused by massive hemolysis when incompatible with Rh and / or AB0 antigens. The objective: The objective: to evaluate the role of redox homeostasis in the formation of the immune response in isoimmune conflict during pregnancy. Results. The results obtained indicate the activation of T- and B-lymphocytes, which may be explained by the activation of cytokines IL-1, IL-6, IL-10. In pregnancy isoimmune conflict moderate metabolic acidosis is observed with a predominance of the lactic acid component and the depletion of buffer reserves. Conclusions. Isoimmune conflict leads to moderate formation of oxidative stress, that can be described as violation of redox-homeostasis, which in turn can be a consequence of cytotoxic reactions.

 Articles related

Katarzyna Kosz,Martyna Zielinska,Natalia Zarankiewicz,Aleksandra Kuchnicka,Jakub Aleksandrowicz,Katarzyna Ksiazek,Sylwia Mojsym-Korybska    

Mindfulness therapy is a psychological process, which main purpose is to concentrate attention on internal and external stimuli in the present moment. Practising mindfulness is correlated with well-being, greater energy and enthusiasm as well as the abil... see more


Andriy B Kul’chyns’kyi,Walery Zukow    

Background.The results of research the influence of balneotherapy in the spa Truskavets’ on the immune status of the organism are ambiguous. This may be due to the differences between the cohorts of the subjects under investigation, and individual immune... see more


A. V. Andreev,B. A. Nasibullin,I. K. Tagunova    

The authors based on the results of a comprehensive examination of 32 patients diagnosed with "Hypertrophy of the lingual tonsil", established that the clinical manifestations of this suffering are combined with dystrophic changes in the parameters of th... see more


Lyubomyr M Zajats,?lona S Polovynko,Walery Zukow    

Background. In the previous report, we showed that the immune response to chronic stress in male rats are characterized by diversity.We assume that a variety of immune responses to chronic stress caused by a variety of reactions neuroendocrine factors.Th... see more


?lona S Polovynko,Lyubomyr ? Zajats,Walery Zukow,Roman I Yanchij,Igor L Popovych    

Polovynko ?lona S, Zajats Lyubomyr ?, Zukow Walery, Yanchij Roman I, Popovych ?gor L. Quantitative evaluation of integrated neuroendocrine and immune responses to chronic stress in rats male. Journal of Education, Health and Sport. 2016;6(8):154-166. eIS... see more